%0 Journal Article
%T Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery
%A Dinesh Kumar
%A Deepak Sharma
%A Gurmeet Singh
%A Mankaran Singh
%A Mahendra Singh Rathore
%J ISRN Pharmaceutics
%D 2012
%R 10.5402/2012/474830
%X Lipid-based innovations have achieved new heights during the last few years as an essential component of drug development. The current challenge of drug delivery is liberation of drug agents at the right time in a safe and reproducible manner to a specific target site. A number of novel drug delivery systems has emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Microparticulate lipoidal vesicular system represents a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. Also, novel lipid carrier-mediated vesicular systems are originated. This paper has focused on the lipid-based supramolecular vesicular carriers that are used in various drug delivery and drug targeting systems. 1. Introduction The turn of century has witnessed a remarkable growth in drug discovery, development, and use. New drug delivery technologies are revolutionizing the development and creating R&D-focused pharmaceutical industries to suit the needs of the modern world. The scenario of pharmaceutical research is being steadily changed, by encouraging development of novel drug delivery of existing drug molecule instead of development of new chemical entities. The novel drug delivery approaches aim to develop a carrier system which can hold the molecule effectively and then navigate them towards the right destination without affecting the physiological conditions of the body. Vesicular system has achieved new heights during the last few years as an essential component of drug development. The phospholipid-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue, cell or intracellular compartment, the control over release kinetics, the protection of the active agent or a combination of the above [1¨C3]. From the last two decades, microparticulate lipoidal vesicular systems have been under extensive investigation as carriers for the improved delivery of a broad spectrum of agents, including chemotherapeutic agents, imaging agents, antigens, immunomodulators, chelating compounds, haemoglobin and cofactors, lipids, and
%U http://www.hindawi.com/journals/isrn.pharmaceutics/2012/474830/