%0 Journal Article
%T Heavy Metal Levels in Adolescent and Maternal Blood: Association with Risk of Hypospadias
%A Tusha Sharma
%A Basu Dev Banerjee
%A Chandra Shekhar Yadav
%A Piyush Gupta
%A Sunil Sharma
%J ISRN Pediatrics
%D 2014
%R 10.1155/2014/714234
%X Background. Hypospadias is a part of testicular digenesis syndrome (TDS) which includes infertility, cryptorchidism, and spermatogenesis. Heavy metals act as endocrine disrupting compounds. Heavy metals such as cadmium, chromium, arsenic, and lead have been associated with male infertility, cryptorchidism, spermatogenesis, cancer, reproductive disorder, and neurological disorder. However, it remains an important issue to corroborate or refute the hypothesis that the role of heavy metals in male reproductive tract disorders. Hence, the present study was designed to investigate the possible association of heavy metal and risk of hypospadias by estimating the blood heavy metal levels. Methods. In this case control study, 50 hypospadias boys diagnosed and confirmed by a pediatric urologist and 50 randomly selected age-matched (1¨C5 years) healthy control boys not suffering from any clinically detectible illness and their mothers have been included and heavy metal levels in the blood of these subjects have been estimated by Atomic Absorption Spectrophotometer (AAS). Result. Significantly high levels of cadmium and lead have been observed in hypospadias cases; however, all heavy metal levels were present in higher concentration. Conclusion. Higher blood levels of cadmium and lead may be associated with the increased risk of hypospadias. 1. Introduction Hypospadias is urogenital birth defect and a part of testicular digenesis syndrome (TDS) which includes infertility, cryptorchidism, and spermatogenesis. The development of the male reproductive organs is controlled by sex hormones, and particular androgen plays a crucial role during the first trimester of pregnancy [1]. Fetal exposure to chemicals with antiandrogen or estrogen-like activity may interfere with normal hormonal signalling, which may increase the risk of hypospadias and other male reproductive disorders [2, 3]. Many chemicals including dioxins and furans, polychlorinated biphenyls, organochlorine pesticides, and some heavy metals have been identified as potential endocrine disrupters [4]. Exposure to heavy metals such as arsenic (As), chromium (Cr), cadmium (Cd), and lead (Pb) is a serious growing concern throughout the world. This exposure has risen dramatically in the last few decades due to an exponential increase in the use of these heavy metals in various industrial processes such as dyeing, metal refining, and plastic. Occupational exposure to heavy metals such as Cd, Cr, and Pb has been reported and has been associated with cancer, reproductive disorder, neurological disorders, and so forth.
%U http://www.hindawi.com/journals/isrn.pediatrics/2014/714234/