%0 Journal Article %T Risk Factors of Antibiotic Misuse for Upper Respiratory Tract Infections in Children: Results from a Cross-Sectional Knowledge-Attitude-Practice Study in Greece %A Sotiria G. Panagakou %A Vassiliki Papaevangelou %A Adamos Chadjipanayis %A George A. Syrogiannopoulos %A Maria Theodoridou %A Christos S. Hadjichristodoulou %J ISRN Pediatrics %D 2012 %R 10.5402/2012/685302 %X Background. Upper respiratory tract infections (URTIs) are common in children. The cause of URTIs is usually viral, but parentsĄŻ attitudes often contribute to inappropriate prescription of antibiotics, promoting antibiotic resistance. The objective of this study was to identify possible risk factors associated with antibiotic misuse in Greece, a country with high levels of antibiotic use and antibiotic resistance. Methods. A knowledge-attitude-practice (KAP) questionnaire was developed and distributed to Greek parents caring for children who were 5-6 years old, between January and July of the same school year. Results. The sample of the study contained 5312 parents from all geographic areas of Greece. The risk factors of being a father, having low education, having immigrant status, being a single parent, having low income, having <2 or >3 children, living in the islands, and being without experience in recurrent URTIs were significantly associated to inadequate knowledge, inappropriate attitudes, and wrong practices. Conclusions. This study has identified the main groups of parents that should be targeted in future intervention programs. 1. Introduction Upper respiratory tract infections (URTIs) in children are mainly due to viral infections [1, 2]. Thus, the benefit from antimicrobial drugs is minimal. However, there is strong evidence that antibiotics are frequently administered to children suffering from URTIs [3, 4]. It appears that both pediatricians and parents are responsible for this antibiotic misuse [5¨C7] which is contributing to the development of resistant strains of bacterial pathogens [8¨C10] and placing a burden on the economy of the health care system. Amongst European countries, Greece presents the highest antibiotic consumption and antibiotic resistance [11]. In order to reveal the contributing factors of this phenomenon, a knowledge, attitude, and practice (KAP) study of Greek parents towards antibiotic use in children suffering from URTIs was performed. The objective of the current study was to identify possible risk factors associated with antibiotic misuse. This would enable the development of intervention strategies aiming to parental education. 2. Materials and Methods 2.1. Study Design and Settings The study sample comprised of parents from all geographic areas of Greece. A school-based stratified geographic clustering sampling was used to select a representative sample of students. Seven thousand seven hundred and four parents (7704) of children aged between 5 and 6 years old participated in the survey. Approval was given by %U http://www.hindawi.com/journals/isrn.pediatrics/2012/685302/