%0 Journal Article
%T Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality
%A Keerti Singh
%A Kandamaran Krishnamurthy
%A Camille Greaves
%A Latha Kandamaran
%A Anders L. Nielsen
%A Alok Kumar
%J ISRN Obstetrics and Gynecology
%D 2014
%R 10.1155/2014/651783
%X Objectives. To study the prevalence and the pattern of major congenital malformations and its contribution to the overall perinatal morbidity and mortality. Methods. It is a retrospective population based study. It includes all major congenital malformations in newborns during 1993-2012. The data was collected from the birth register, the neonatal admission register and the individual patient records at the Queen Elizabeth Hospital where over 90% of deliveries take place and it is the only facility for the care of sick newborns in this country. Results. The overall prevalence of major congenital malformations among the live births was 59/10,000 live births and that among the stillbirths was 399/10,000 stillbirths. Circulatory system was the most commonly affected and accounted for 20% of all the major congenital malformations. Individually, Down syndrome (4.1/10, 000 live births) was the commonest major congenital malformation. There was a significant increase in the overall prevalence during the study period. Major congenital malformations were responsible for 14% of all neonatal death. Conclusions. Less than 1% of all live newborns have major congenital malformations with a preponderance of the malformations of the circulatory system. Major congenital malformations contribute significantly to the overall neonatal morbidity and mortality in this country. 1. Introduction Congenital malformation is defined as Ħ°a permanent change produced by an intrinsic abnormality of development in a body structure during prenatal lifeĦħ [1]. Reported prevalence of major congenital malformations in different population around the world has shown considerable variation and ranges from less than 1% to up to 8% [2¨C9]. The varying pattern and prevalence of congenital malformations over time or geographical location may reflect differing methods of detection and recording or true differences in frequency due to the complex interaction of known and unknown genetic and environmental factors including sociocultural, racial, and ethnic variables. For quite some time, congenital malformations have been reported to be a major cause of mortality and morbidity in children in the developed countries [10¨C15]. Contrary to the commonly held view that congenital disorders are not a public health issue in developing countries, in recent years, a number of developing countries are in fact experiencing an epidemiological transition, with significant declines in infant mortality rates, reduction of infections and malnutrition and a relative increase of morbidity and mortality due to
%U http://www.hindawi.com/journals/isrn.obgyn/2014/651783/