%0 Journal Article
%T Genital Infection with Herpes Simplex Virus Types 1 and 2 in Women from Natal, Brazil
%A Cleine Aglacy Nunes Miranda
%A ¨¦rika Galv£¿o Lima
%A Diego Breno Soares de Lima
%A Ricardo Ney Oliveira Cobucci
%A Maria da Concei£¿£¿o de Mesquita Cornetta
%A Thales Allyrio Ara¨²jo de Medeiros Fernandes
%A Paulo Roberto Medeiros de Azevedo
%A Jenner Chrystian Ver¨ªssimo de Azevedo
%A Jos¨¦lio Maria Galv£¿o de Ara¨²jo
%A Jos¨¦ Ver¨ªssimo Fernandes
%J ISRN Obstetrics and Gynecology
%D 2014
%R 10.1155/2014/323657
%X Objective. To evaluate the prevalence of HSV-1 and HSV-2 in pregnant and nonpregnant women, testing the correlation between DNA of the viruses with colposcopic and/or cytological changes, and evaluate association with sociodemographic characteristics and sexual activity. Methods. Included in this study were 106 pregnant and 130 nonpregnant women treated at primary health care units of Natal, Brazil, in the period 2010-2011. The patients were examined by colposcopy, and two cervical specimens were collected: one for cytology examination and another for analysis by PCR for detection of HSV-1 and HSV-2. Results. HSV-1 alone was detected in 16.0% of pregnant and 30.0% of nonpregnant women. For HSV-2, these rates were 12.3% and 15.5%, respectively. HSV-2 had a higher correlation with cytology and/or colposcopy changes than HSV-1 did. Genital HSV-1 infection was not associated with any of the variables tested, whereas HSV-2 infection was associated with ethnicity, marital status, and number of sexual partners. Conclusions. The prevalence of HSV-1 was higher than that observed for HSV-2 in both pregnant and nonpregnant women. The genital infection by HSV-2 was higher in women with changed colposcopy and/or cytology, and it was associated with ethnicity, marital status, and number of sexual partners. 1. Introduction Herpes simplex virus (HSV) is a neurotropic virus that has a large linear, double-stranded DNA genome protected by a capsid with icosahedral symmetry surrounded by an envelope consisting of a lipid bilayer with embedded glycoproteins, having yet a proteinaceous region between the capsid and envelope called tegument [1]. The HSV belongs to the family of Herpesviridae, subfamily Alphaherpesvirinae, and genus Simplex virus [2, 3]. It is a virus that has a very complex life cycle and stands out as one of the most common pathogens in the etiology of sexually transmitted diseases worldwide [4]. HSV infects the mucosa of the mouth, eyes, and the human anogenital tract. After primary infection, the virus replicates productively within mucosal epithelial cells and enters sensory neurons via nerve termini. The virus is then transported to neuronal cell bodies where latency is established. The virus can remain in this latent state indefinitely but can be reactivated at any time during the lifetime of the host [4, 5]. During latent infection, no infectious virus is produced from infected cells, symptoms are absent in the host, and the transmission does not occur. However, reactivation can occur only in some cells, in the absence of symptoms, enabling the
%U http://www.hindawi.com/journals/isrn.obgyn/2014/323657/