%0 Journal Article
%T Effect of Coadministration of Neurovite and Lamivudine on the Histomorphology of the Cerebellum of Wistar Rats
%A A. I. Peter
%A M. B. Ekong
%A K. Davies
%A O. O. Azu
%A R. B. Bassey
%A L. O. Ugwu
%A I. U. Umoh
%J ISRN Neuroscience
%D 2014
%R 10.1155/2014/258040
%X Introduction. Lamivudine is a nucleoside reverse transcriptase inhibitor antiretroviral agent used in the treatment of human immunodeficiency virus type 1 infection. This study was to investigate the effects of coadministration of neurovite and lamivudine on the histomorphology of the cerebellum of Wistar rats. Materials and Methods. Twenty Wistar rats were divided equally into four groups. Group A animals were the control treated with distilled water. Groups B, C, and D animals were treated, respectively, with therapeutic dose of lamivudine (4.28£¿mg/kg), a combination of lamivudine (4.28£¿mg/kg) and neurovite (7.05£¿mg/kg), and neurovite (7.05£¿mg/kg) alone, daily. The rats were sacrificed using chloroform inhalation, processed, and stained using H&E method. Results. There was severe cellular degeneration with dystrophic changes, vacuolization in the molecular and granular layers, and aggregation of swollen Purkinje cells in group B animals compared with group C animals which showed only slight cellular dystrophy and inflammation. The mean cellular population was significantly ( ) higher in the treatment groups compared with the control. Conclusion. There was amelioration of damage of the cerebellum in the animals treated with neurovite and lamivudine combination compared to animals treated with only lamivudine. Therefore, there is need to give neurovite to patients on lamivudine therapy. 1. Introduction Lamivudine (INN)6 or 3TC is a levorotary pyrimidone-1,3-oxathiolane derivative and has the molecular formula C8H11N3O3S. Lamivudine is an effective and well-tolerated agent for treating chronic hepatitis B infection and acquired immunodeficiency syndrome [1, 2]. It is an antiretroviral drug in the therapeutic category of nucleoside reverse transcriptase inhibitor [2]. Lamivudine is very useful in preventing HIV and hepatitis B from multiplying by way of its active form, lamivudine triphosphate (3TCTP) which is generated via intracellular triple phosphorylation process. Lamivudine competitively inhibits viral transcriptase by causing termination of DNA replication, thus interrupting HIV replication [3]. Antiretroviral treatment can significantly prolong the lives of people living with HIV. Modern combination therapy is highly effective and people with HIV and on antiretroviral treatment could live for the rest of their lives without developing AIDS [4]. Despite these improvements, the prolonged use of highly active antiretroviral therapy (HAART) has led to certain neurologic complications such as myelopathy, neuropathy, neuropathic pain, and cognitive
%U http://www.hindawi.com/journals/isrn.neuroscience/2014/258040/