%0 Journal Article
%T Association of Intracranial Aneurysms with Meningiomas, Pituitary Adenomas, and Gliomas: Review of Possible Interrelationships
%A Kevin Spitler
%A Doniel Drazin
%A George Hanna
%A Ashish Patel
%A Ray Chu
%J ISRN Neurology
%D 2013
%R 10.1155/2013/383425
%X Asymptomatic intracranial abnormalities are increasingly becoming a focus of attention with the utilization of high-resolution imaging. The concurrence of tumor and aneurysm has been described, largely, by case reports and single-surgeon experiences. Recent papers have outlined the ethics of incidental findings and possible treatment algorithms. Incidental finding of an aneurysm occurs most commonly in patients with meningiomas, pituitary adenomas, and gliomas. Such an association may explain the mechanisms of aneurysm formation, growth, and rupture in acromegalic patients; however, insufficient data are available to link aneurysm with either glioma or meningioma. 1. Introduction The radiographic characterization of a primary lesion may present a new clinical issue when a second asymptomatic intracranial lesion is identified. This issue is expected to become increasingly more frequent as the resolution of neuroimaging progresses [1, 2]. The ethics and clinical approach algorithm is currently under discussion [3]; however, the relationship between two concurrent intracranial lesions is not completely understood. The existence of a single lesion has been hypothesized to initiate additional lesions in the brain [4]. The occurrence of tumor together with aneurysm has been noted in case reports and series, but a comparison between tumor types and aneurysm location has been rarely studied. Our focus is to document the concurrence of aneurysm and tumor across the literature and to describe the treatment outcomes, including observation. We hope to achieve a new understanding of the possible associations of meningiomas, pituitary adenomas, and gliomas with aneurysm formation, growth, and rupture. 2. Methods 2.1. Literature Review Articles were identified from a systematic literature review using PubMed and MEDLINE databases for the years 1950 through 2012 with the following search terms: ¡°cerebral aneurysm,¡± ¡°intracranial aneurysm,¡± ¡°brain tumor,¡± ¡°meningioma,¡± ¡°glioma,¡± ¡°glioblastoma multiforme,¡± ¡°pituitary adenoma,¡± ¡°ruptured,¡± ¡°unruptured,¡± and/or ¡°subarachnoid hemorrhage.¡± Additional publications were located and reviewed based on the references in the articles obtained from the database searches. Inclusion criteria required that appropriate articles be published as full-length articles in a peer-reviewed, English language journal. Studies were excluded if the co-occurrence of tumor and aneurysm could be separated. For example, aneurysms were excluded which appeared to develop within a postoperative area or that were labeled as pseudoaneurysms. If multiple
%U http://www.hindawi.com/journals/isrn.neurology/2013/383425/