%0 Journal Article
%T Cognitive Dysfunction and Dementia in Primary Sj£¿gren¡¯s Syndrome
%A Frederic Blanc
%A Nadine Longato
%A Barbara Jung
%A Catherine Kleitz
%A Laure Di Bitonto
%A Benjamin Cretin
%A Nicolas Collongues
%A Christelle Sordet
%A Marie Fleury
%A Vincent Poindron
%A Jacques-Eric Gottenberg
%A Olivier Anne
%A Dan Lipsker
%A Thierry Martin
%A Jean Sibilia
%A J¨¦r£¿me de Seze
%J ISRN Neurology
%D 2013
%R 10.1155/2013/501327
%X Background. Primary Sj£¿gren¡¯s syndrome (PSS) is a frequent systemic autoimmune disease. In this study, we aimed to explore the cognitive impairment and the correlations with brain MRI. Methods. Twenty-five patients (mean age 55 ¡À 11.8 years, 21 females) with PSS were prospectively selected and tested with a French translation of the Brief Repeatable Battery for Neuropsychological Examination. The results were compared with the scores for 25 matched patients with multiple sclerosis (MS) and 25 controls. Brain lesions were assessed by brain MRI using the Wahlund classification. Results. Fifteen of the 25 PSS patients (60%) presented with cognitive disorders versus 19/25 MS patients (76%). Five patients had dementia in the PSS group. Speed of information processing, attention, immediate and long-term memory, and executive functions were frequently impaired. The mean duration of cognitive complaints was 5.6 ¡À 6.1 years, and the mean duration of PSS was 15.8 ¡À 14.0 years. A trend towards a correlation was found between the severity of cognitive impairment and the degree of white matter lesions (WML) ( , rho = 0.43). Conclusion. Cognitive impairment¡ªmild or dementia¡ªexists in patients with PSS. Further MRI studies are needed to better understand the precise neural basis of cognitive impairment in PSS patients. 1. Background Primary Sj£¿gren¡¯s syndrome (PSS) is a frequent systemic autoimmune disease, characterized by mononuclear infiltration of salivary and lachrymal glands, leading to xerostomia and xerophthalmia (sicca syndrome). Neurological manifestations are observed in 8.5£¿42% of cases [1]. Delalande et al. reported central nervous system involvement in 56 out of 82 patients (68%) with PSS and neurological manifestations [2]. Cognitive manifestations have been observed in 10¨C50% of PSS patients [3¨C8]. Few studies have described the cognitive pattern of PSS [4, 5]. This study examined PSS patients and compared the cognitive pattern and the severity of cognitive impairment to those seen in patients with multiple sclerosis (MS) and the correlations with brain lesions on magnetic resonance imaging (MRI). 2. Patients and Methods Twenty-five consecutive patients (mean age 55 years, range 30¨C74, 21 women and 4 men) with PSS diagnosed according to American-European Consensus Group criteria [9] were evaluated prospectively at the Neuropsychology unit of the University Hospital of Strasbourg from January 2008 to April 2012. Six patients were diagnosed for PSS at the Neuropsychology unit the others were diagnosed for PSS previously, because of rheumatological and/or
%U http://www.hindawi.com/journals/isrn.neurology/2013/501327/