%0 Journal Article
%T Antioedematous and Analgesic Properties of Fertile Fronds of Drynaria quercifolia
%A G. I. Anuja
%A P. G. Latha
%A V. J. Shine
%A S. R. Suja
%A P. Shikha
%A K. Satheesh Kumar
%A S. Rajasekharan
%J ISRN Inflammation
%D 2014
%R 10.1155/2014/302089
%X Inflammation is a complex biological response of tissue cells to harmful stimuli including trauma, tissue necrosis, and infections which plays a key role in the pathophysiology of many deadly diseases. In ethnomedicine Drynaria quercifolia fronds are used to treat inflammation as poultice on swellings and as antibacterial, hepatoprotective, and antipyretic agent. Herein, we have evaluated the antioedematous, antiproliferative, and analgesic properties of the ethanolic extract of fertile fronds of D. quercifolia (FF) by standard procedures. Oral administration of FF produced significant inhibition of carrageenan and histamine induced paw oedema in Wistar rats. FF significantly reduced both wet weight and dry weight of granuloma tissue which shows the inhibitory effect on exudative and proliferative phases of inflammation. FF significantly attenuated acute and delayed phases of formalin induced pain, acetic acid-induced writhing, capsaicin-induced nociception, and hot plate test in mice. Phytochemical analysis revealed the presence of coumarins, flavonoids, glycosides, phenolics, saponins, steroids, tannins, and terpenoids. Total phenolic content was 186£¿mg/g equivalent of gallic acid. The HPLC estimation showed flavanone glycoside naringin (1.2%) and its aglycone naringenin (0.02%). The presence of potent anti-inflammatory and analgesic principles in FF and their synergistic action may be the reason for the proposed therapeutic effects. 1. Introduction Inflammation is a complex biological response of tissue cells to harmful stimuli including mechanical trauma, tissue necrosis, and infections which plays a key role in the pathophysiology of many deadly diseases including Alzheimer¡¯s disease, Type 2 diabetes, rheumatoid arthritis, liver cirrhosis, cancer, and neurological, pulmonary, and cardiovascular diseases. Although several modern drugs are used to treat these types of disorders, their prolonged use may cause severe adverse side effects [1]. Consequently there is a need to develop new anti-inflammatory agents with minimum side effects [2]. Most of the present day analgesic drugs also exert a wide range of side effects [3]; a study on plant species that are traditionally used as pain killers must be adopted as a research strategy in the development of analgesic drugs [4]. Herbal drugs play a major role in the treatment of human ailments due to their safety, efficacy, and cost effectiveness [5]. Dependence on plants as a source of medicine is prevalent in developing countries where traditional medicine plays a major role in health care [6]. Infectious
%U http://www.hindawi.com/journals/isrn.inflammation/2014/302089/