%0 Journal Article
%T Growth and Specialized Growth Charts of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Isfahan, Iran
%A Awat Feizi
%A Mahin Hashemipour
%A Silva Hovsepian
%A Zeynab Amirkhani
%A Roya Kelishadi
%A Maryam Yazdi
%A Kamal Heydari
%A Ali Sajadi
%A Masoud Amini
%J ISRN Endocrinology
%D 2013
%R 10.1155/2013/463939
%X Objectives. The aim of the current study was to investigate the growth status of CH, generate specialized growth charts of CH infants, and compare them with their counterparts of regional normal infants. Methods. In this prospective cohort study, 760 (345 girls and 415 boys) neonates born in 2002¨C2009 diagnosed by neonatal CH screening program in Isfahan were followed up from the time of diagnosis. 552 healthy children were recruited as a control group. The empirical 3rd, 15th, 50th, 85th, and 97th percentiles for height, weight, and head circumference of both sexes were determined and compared with their counterpart values of the control group. The relative frequency of patients with impaired growth for each studied variable was determined. Also, specialized growth charts of CH patients were generated. Results. The percentiles of weight, height, and head circumference of studied patients are significantly different from regional healthy children ( ). The relative frequency of impaired head circumference was decreased to less than 3% at the 3rd year of age and for height it reached gradually 3% and 9% at the 5th year of age for boys and girls, respectively ( ); however for weight still it was statistically more than 3% in both sexes. Conclusion. CH patients had impaired growth development which was improved during follow up, but the catch-up time was earlier for head circumference and later for weight. 1. Introduction Thyroid hormones are essential for appropriate growth and development during fetal life and neonatal period [1]. Congenital hypothyroidism (CH), the most common neonatal endocrine and metabolic disorder, is considered as the preventable cause of mental and growth retardation [2]. Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, affecting 1 in 3000 to 4000 newborns. The prevalence varies depending on the race/ethnicity and the method of screening [2¨C7]. Although screening programs ensure early treatment, developmental problems in relation to physical and mental outcomes are still reported in follow-up studies in developing and even in developed nations [8¨C10]. CH screening in Isfahan, one of the biggest central provinces in Iran, has been started in 2002 as a pilot study which continued till 2005 and because of high prevalence of the disorder, that is, 1£¿:£¿370 in 2002 [7] and 1£¿:£¿748 in 2009 [11], it was adapted as a nationwide screening program in Iran and is continuing till now [11]. Many studies have already been performed and published regarding the high prevalence and its environmental, genetic, and
%U http://www.hindawi.com/journals/isrn.endocrinology/2013/463939/