%0 Journal Article
%T The Role of Interleukin-1 Genotype in the Association between Coronary Heart Disease and Periodontitis in a Syrian Population
%A Lina Bashour
%A Razan Khattab
%A Elham Harfoush
%J ISRN Dentistry
%D 2013
%R 10.1155/2013/195678
%X Objective. To determine whether differences exist between periodontitis subjects with and without Coronary Heart Disease (CHD) in a Syrian population in the distribution of IL-1 alleles at positions IL-1 +4845, IL-1 +3954, IL-1 £¿511, and IL-1RN VNTR. Background. The role of Interleukin-1 genes in the association between periodontitis and CHD has been demonstrated in previous studies. No study has been carried out on the Syrian population to asses for such a role. Methods. 200 Syrian Arab periodontitis patients (184 males, 16 females; mean age 52.61) were divided into two groups: cases group 100 subjects with CHD (92 males, 8 females; mean age 52.06); controls group 100 subjects without CHD (92 males, 8 females; mean age 53.16). Probing depth (PD), clinical attachment loss (CAL), and alveolar bone loss (ABL) were performed for patients. Blood samples were collected for genotyping analysis of IL-1 +4845, IL-1 +3954, and IL-1 £¿511 using PCR-RFLP technique and IL-1RN VNTR using normal PCR. Results. An association between both (CAL and ABL) and CHD was shown after adjustment for other confounders (OR: 7.659, ; OR: 3.645, , resp.). Also, an association between allele 2 of IL-1 +4845, IL-1 +3954, and IL-1 £¿511 and ABL was shown. Allele 2 of IL-1 +4845 and IL-1 £¿511 was associated with ABL among individuals with and without CHD. But after adjustment for other confounders, the association remained only between allele 2 of IL-11 +4845 and both CHD and severe ABL (OR: 0.189, ). Conclusion. Allele 2 of IL-11 +4845 may be considered a risk indicator for having both CHD and severe ABL in the investigated Syrian population. 1. Introduction Periodontitis is a chronic inflammatory disease of multifactorial etiology initiated by specific bacteria that activate host mechanisms which in turn destroy the bone and connective tissues that support the teeth [1]. In recent years, studies have demonstrated that periodontitis is associated with elevated levels of inflammatory cytokines [2], which have a substantial impact on numerous biological activities, and they take part in triggering inflammatory cascades and systems [3]. To illustrate, Interleukin-1 (IL-1) plays a prominent role in the inflammatory response in periodontal lesions. IL-1¦Á and IL-1¦Â upregulate prostaglandin E2 and matrix metalloproteinase and, together with these components, promote the loss of connective tissue and bone in periodontitis lesions [4]. Atherosclerosis is considered the most common cause of Coronary Heart Disease (CHD). It is a variable combination of changes of the intima of arteries that lead
%U http://www.hindawi.com/journals/isrn.dentistry/2013/195678/