%0 Journal Article %T Mathematical Modeling and Computational Simulation of a New Biomedical Instrument Design %A Zheng Jeremy Li %J ISRN Biomathematics %D 2012 %R 10.5402/2012/256741 %X Endo surgiclip instrument is the biomedical instrument that can be applied for endoscopic surgery to assist surgeons in homeostasis and secure mucosal gap surfaces during surgical operations. Since some clinic feedbacks show the surgiclip drop-off incidents which can potentially sever organ and tissue, the improvement of endo surgiclip instrument has been made in these years. Since few research papers were involved in the study of endo surgiclip instrument performance via mathematical modeling and computational simulation, currently some instrumental modifications are mainly based on clinic lab tests which prolong the improvement cycle and increase additional manufacturing cost. This paper introduces a new biomedical surgiclip instrument based on mathematical modeling, computer-aided simulation, and prototype testing. The analytic methodology proposed in this paper can help engineers in biomedical industry develop and improve biomedical instrument. Compared to the current conventional surgiclip instruments, this new surgiclip instrument can properly assist surgeon in surgical procedure with less operational force and no surgiclip drop-off incident. The prototype has also been built and tested. Both computational simulation and prototype testing show close results which validate the feasibility of this newly developed endo surgiclip instrument and the methodologies of mathematical modeling based computational simulation proposed in this paper. 1. Introduction Biomedical/surgical instruments are renovated and technology-based devices requiring continuous improvement to guarantee safe use in surgery and be able to compete the challenging market [1]. The endo surgiclip instruments are commonly applied in surgical operations to repair biological defects, such as the anastomotic leakage in the gullet or gorge [2]. Recent researches indicate the flexibility and adaptability of endoscopic surgiclip instruments in curative and healing operation [3]. Endo surgiclip instruments can be applied in haemostasis using endoscopy to GI tract to repair the damaged tissues [4]. The biomedical/surgical instrument development is usually measured and controlled for its better functionality, proved feasibility, validated safety, improved reliability, and cost-effective productivity [5]. The functionality of biomedical surgiclip instruments is judged by the levels of bodily wound and tissue disturbance that biomedical devices might cause the patients [6]. The less-invasive biomedical/surgical instruments can be developed with advances of renovated surgical technique, improved %U http://www.hindawi.com/journals/isrn.biomathematics/2012/256741/