%0 Journal Article
%T Effect of Two Different Doses of Gabapentin on the Intraocular Pressure and Hemodynamic Stress Responses to Laryngoscopy and Tracheal Intubation
%A Amani A. Ali
%A Abeer M. Elnakera
%A Ahmed Samir
%J ISRN Anesthesiology
%D 2013
%R 10.1155/2013/698205
%X Background. The stress response to laryngoscopy and intubation causes an undesirable increase in heart rate, blood pressure, and intraocular pressure. This study was designed to compare the effect of two doses of gabapentin on the stress response to laryngoscopy and intubation. Patients and Methods. (ASA I and II) 60 patients, aged from 18 to 60 years undergoing elective eye surgery requiring endotracheal intubation, were randomly allocated into 3 groups, 20 patients each. 2 hours before the surgery, group I received oral placebo, and groups II and III received oral gabapentin 800£¿mg and 1200£¿mg, respectively. Heart rate (HR), mean arterial pressure (MAP), and intraocular pressure (IOP) were measured before and after induction of anesthesia, immediately after, 5 minutes, and 10 minutes after intubation. Results. Gabapentin 1200£¿mg prevented the increase in HR, MAP, and IOP, secondary to laryngoscopy and intubation, and kept them below the baseline till 10 minutes after intubation ( ), while with gabapentin 800£¿mg, the increase in HR, MAP, and IOP was nonsignificant ( ) and returned to levels below the baseline at 5 and 10 minutes after intubation. Conclusion. Preoperative gabapentin 1200£¿mg effectively prevented the stress response to laryngoscopy and intubation; meanwhile, gabapentin 800£¿mg only prevented significant stress response. 1. Introduction Laryngoscopy and endotracheal intubation can evoke a transient but marked response manifested as hemodynamic changes such as hypertension, tachycardia, even dysrhythmias, and an increase in intraocular pressure [1, 2]. The hemodynamic responses to laryngoscopy and intubation can be tolerated by a normal subject but they may be dangerous increasing the morbidity and mortality in patients with hypertension and ischemic heart disease [3]. The control of intraocular pressure (IOP) is of prime importance in eye surgery especially in penetrating eye injury and glaucoma surgery [4]. Many pharmacologic agents have been proposed to attenuate the stress response to laryngoscopy and intubation such as systemic and local lidocaine, B blockers, calcium channel blockers, vasodilators, and opioids [5¨C7]. In the past few years gabapentin has been used in anesthetic practice as an analgesic in the perioperative setting and has been noticed to provide hemodynamic stability, so some studies have been conducted to test the effect of gabapentin by different doses on the stress response to laryngoscopy and intubation and yielded different results [8, 9]. This study was designed as a prospective randomized double-blinded
%U http://www.hindawi.com/journals/isrn.anesthesiology/2013/698205/