%0 Journal Article
%T Canine Choroid Plexus Tumor with Intracranial Dissemination Presenting as Multiple Cystic Lesions
%A Trisha J. Oura
%A Peter J. Early
%A Samuel H. Jennings
%A Melissa J. Lewis
%A Jeremy R. Tobias
%A Donald E. Thrall
%J Case Reports in Veterinary Medicine
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/759054
%X A Miniature Pinscher developed acute blindness and behavioral changes. On magnetic resonance imaging (MRI), there were multiple small intra-axial cystic lesions, and primary differential diagnoses included primary or metastatic neoplasia and neurocysticercosis. These cystic lesions were subsequently diagnosed histopathologically as disseminated choroid plexus carcinoma. This is only the second documented description of this diagnosis in a dog, but both patients had very similar MRI findings. This patient adds to the literature about the MRI characteristics of choroid plexus tumors and indicates that choroid plexus tumor should be considered as a possible cause of small multifocal intra-axial cystic brain lesions in dogs, regardless of whether a primary intraventricular lesion is visible. 1. Introduction Choroid plexus tumors arise from the epithelium of the choroid plexus and account for approximately 10% of all primary intracranial tumors in dogs [1]. These predominantly benign tumors are found most commonly in the lateral, third, or fourth ventricles. Dogs are typically middle-aged at the time of presentation, and males and Golden Retrievers may be overrepresented [1]. Clinical signs, which can include ataxia, circling, blindness, and behavior changes, are often due to hydrocephalus as ventricular lesions may cause cerebrospinal fluid (CSF) accumulation due to obstruction and/or overproduction [1, 2]. Definitive diagnosis of choroid plexus tumors is by histopathologic evaluation; however, there are often distinctive findings on magnetic resonance imaging (MRI), such as well-differentiated, irregularly margined, intraventricular masses. These masses are typically hyperintense on T2 and proton density (PD) sequences with strong, homogeneous contrast enhancement [3]. Perilesional edema may be present or absent, and primary choroid plexus tumors may contain foci of hemorrhage or mineralization [3]. Both choroid plexus papillomas and carcinomas can metastasize, often to the spinal subarachnoid space, creating the so-called drop metastases. Rarely, tumor dissemination and meningeal carcinomatosis of choroid plexus tumors have been documented, with spread of neoplastic cells within the leptomeninges [4, 5]. Although documented histologically [5], there has been only one prior report of the MRI findings of a dog with choroid plexus carcinoma and secondary leptomeningeal metastases [4, 5]. The purpose of this report is to add information from one additional patient with this interesting and unusual manifestation of choroid plexus tumor. 2. Case Presentation A
%U http://www.hindawi.com/journals/crivem/2013/759054/