%0 Journal Article
%T Metastatic Mucinous Adenocarcinoma of the Prostate with PSA Value of 8.6£¿ng/mL at 5-Year-Followup after Prostatectomy, Radiotherapy, and Androgen Deprivation
%A Christos Kalaitzis
%A Michael Koukourakis
%A Stilianos Giannakopoulos
%A Alexandra Giatromanolaki
%A Efthimios Sivridis
%A Athanasios Bantis
%A Stavros Touloupidis
%J Case Reports in Urology
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/218628
%X Introduction. Mucinous adenocarcinoma of the prostate is a rare variant of prostate cancer. Its malignant potential and the clinical course of the affected patients remain, by and large, controversial. No data exist about the course of metastatic mucinous adenocarcinoma of the prostate. Case Presentation. This case report describes the excellent clinical course of a 68-year-old patient with metastatic mucinous adenocarcinoma of the prostate, treated by radical prostatectomy, irradiation, and androgen deprivation. Conclusion. In our case, mucinous adenocarcinoma of the prostate does not appear to behave differently than acinar prostate cancer. Its malignant potential is dependent on its Gleason score. 1. Introduction Mucinous adenocarcinoma of the prostate is one of the least common morphological variants of prostate cancer, defined by the presence of pools of extraluminal mucin involving at least 25% of the tumor volume at prostatectomy. Mucinous adenocarcinoma is very rare with an incidence of approximately 0.2% [1¨C3]. Grading and prognosis of this rare variant of prostate cancer remain controversial [2, 4, 5]. In previous publications, urologic pathologists have proposed that all colloid carcinomas should be considered, by definition, as a Gleason 8 [1, 4, 5]. Recent articles, however, suggest that the Gleason score should be assigned on the basis of the underlying glandular architecture, irrespective of the presence of mucin [6, 7]. Several case reports have described an aggressive clinical course of mucinous adenocarcinoma of the prostate [1, 8¨C11]. Yet, Osunkoya et al. in a series of 47 cases showed an excellent prognosis for mucinous adenocarcinoma of the prostate [12]. There are no data about the course of metastatic mucinous adenocarcinomas of the prostate. We report herewith the clinical course of a mucinous adenocarcinoma of the prostate with metastasis to iliac lymph nodes at a PSA value of 8.6£¿ng/mL treated by radical prostatectomy, followed by irradiation and androgen deprivation according to Vancouver protocol. 2. Case A 68-year-old Caucasian man was admitted to hospital with a diagnosis of prostate cancer (Gleason score , PSA value 8.6£¿ng/mL), after taking a biopsy in an external urological surgery. CT scan and bone scan were negative for metastases. We treated the patient with retropubic open prostatectomy and standard iliac lymphadenectomy. Frozen section of lymph nodes was not performed because of a PSA < 10£¿ng/mL. Histopathological examination confirmed the presence of a prostatic adenocarcinoma with extraluminal mucinous pools
%U http://www.hindawi.com/journals/criu/2014/218628/