%0 Journal Article
%T Lymphoepithelioma-Like Carcinoma of the Lung: An Unusual Case and Literature Review
%A Yuan-Chun Huang
%A Ching Hsueh
%A Shang-Yun Ho
%A Chiung-Ying Liao
%J Case Reports in Pulmonology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/143405
%X We described a case of lymphoepithelioma-like carcinoma (LELC) of the lung of a 65-year-old man with initial symptoms of intermittent chest pain and mild shortness of breath for 2 weeks. A right-lung mass was noted on chest computed tomography (CT) scan and was proved histopathologically as LELC of lung after video-assisted thorascopic lobectomy. He was successfully treated with lobectomy with postoperative adjuvant chemotherapy and is alive without signs of recurrence for 36 months after the diagnosis. It is important for clinicians, pathologists, and radiologists to understand the clinical, pathological, and radiological presentations of this neoplasm to avoid improper clinical decision making and misdiagnosis. 1. Introduction LELC of the lung was first reported in 1987 [1]. Primary LELC of the lung is a rare entity that has recently been included as a subtype of variants of large cell carcinoma in the World Health Organization¡¯s histologic classification of lung tumors [2]. Being a rare entity and mostly seen in Asians, few cases have been described previously [3]. The behavior of LELC of the lung is reported to be highly variable [4]. LELC has been reported in pharyngeal and foregut derivatives including the oral cavity, salivary glands, thymus, lungs, and stomach [5]. The association with Epstein-Barr virus (EBV) is variable [6]. Primary LELC of the lung is rare. The literature of LELC of the lung involves just more than 150 cases until 2006 [3]. In majority, those patients are Orientals, with nearly two-thirds arising from Taiwan, Southern China, and Hong Kong [3]. We present an unusual case with a pulmonary mass on CT scan of the thorax which was subsequently proved as a LELC of the lung and a brief review of the relevant literature. 2. Case Report The patient is a 65-year-old Taiwanese man, a businessman with initial symptoms of intermittent chest pain with mild shortness of breath for two weeks. Chest X-ray showed a mass lesion in the right lower lung field. Chest CT scan showed a £¿mm heterogeneously enhanced mass lesion with well-defined margin and lobulated contour in the right middle lobe of lung, abutting the mediastinum (Figure 1). Bronchoscopy showed no endobronchial lesion. He received video-assisted thorascopic lobectomy of right middle lobe of lung and mediastinal lymph nodes dissection. Figure 1: (a) Chest X-ray showed a mass lesion in the right paramediastinal region (arrow); (c) Noncontrast-enhanced CT scan: an isodensity lobulated mass lesion in the right middle lobe of lung; ((b) and (d)) Chest CT scan showed a £¿mm heterogenously
%U http://www.hindawi.com/journals/cripu/2013/143405/