%0 Journal Article
%T Oral Cellular Neurothekeoma
%A Nader Emami
%A Faisal Zawawi
%A Rania Ywakim
%A Ayoub Nahal
%A Sam J. Daniel
%J Case Reports in Otolaryngology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/935435
%X Cellular neurothekeoma is known as a cutaneous tumor with uncertain histogenesis. Very little involvement of mucosal membrane has been reported in the literature so far. This is a case report of an intraoral lesion in a 15-years-old girl. Histopathologic evaluation showed a tumor-consists of spindle to epitheloid cells forming micronodules in a concentric whorled shape pattern. Tumor cells were positive for CD63, vimentin, and NKI-C3. Total excision was performed and no recurrence happened after 16-month followup. 1. Introduction Neurothekeoma (NTK) is a generally accepted term for a rare type of benign dermal tumours originating from nerve sheath, first proposed by Gallager and Helwig in 1980 [1]. This entity was previously described and known as nerve sheath myxoma. Cellular NTK was later identified as a subtype based on histopathological and immunohistological features [2, 3]. It is generally a cutaneous lesion, and mucosal involvement has been rarely reported. These numbers are even less in case of cellular variant [4]. This is a report of a cellular neurothekeoma of the oral cavity in a 15-years-old girl. 2. Case Report This study is approved by the Research Ethics Board of the Montreal Children's Hospital and exempted from a full review. A 15-year-old girl presented with a painless submucosal nodule on the anterior right side of the floor of the mouth measuring 0.8£¿cm in the largest dimension for an unknown duration (Figure 1). The patient had no other signs or symptoms. Figure 1: Intraoral submucosal lesion on the right side of the floor of the mouth of a 15-years-old girl, diagnosed with cellular neurothekeoma after biopsy. Her past medical history included acute lymphoblastic leukemia (ALL), diagnosed at the age of 2 years requiring irradiation followed by bone marrow transplant. She has been in remission ever since. She also has a history of multiple acquired nevi which have been biopsied and returned benign. An incisional biopsy was attempted to make the final diagnosis. The pathology report showed cellular NTK. A completion surgery was then performed. There has been no sign of recurrence after 8 months of followup. 3. Histologic and Immunologic Evaluation The excised lesion measures 8£¿mm in the greatest dimension. Microscopic evaluation of hematoxyline-and-eosin- (H&E-) stained slides showed an unencapsulated neoplasm composed of spindle to epitheloid cells, arranged in well formed micronodules with concentric whorled shape appearance. Mucosa was widely involved and some invasion to submucosa was observed. Most of the neoplastic cells
%U http://www.hindawi.com/journals/criot/2013/935435/