%0 Journal Article
%T Ulcerative Lesions in Behcet's Disease
%A ¨¹mit T¨¹rsen
%A Belma T¨¹rsen
%J Ulcers
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/146797
%X Ulcerative lesions in Behcet¡¯s disease (BD) are regarded as important manifestation for diagnosis. Various kinds of ulcerative lesions appear in patients with BD. They present as orogenital ulcers, necrotizing vasculitis and pyoderma gengrenosum. Gastrointestinal system involvement (Gis) in Beh£¿et¡¯s disease affects all areas from the esophagus to the anus. Most authors believe that the Gis manifestations of Beh£¿et¡¯s disease should be confined to aphthous ulcers, which can occur throughout the Gis tract. All patients with oro-genital and Gis ulcerations should be fully investigated to establish a definitive diagnosis and eliminate the possibility of an underlying BD. 1. Introduction BD was first defined by Beh£¿et, a Turkish Professor of Dermatology, in 1937 as a triad of recurrent aphthous stomatitis, genital aphthae, and relapsing uveitis [1]. During the ensuing 65 years multiple systemic associations of the disease including articular, vascular, gastrointestinal, cardiopulmonary and neurologic involvement have become increasingly apparent [2¨C4]. Although the etiology and pathogenesis is not clearly defined, genetic predisposition, infections and immunological dysfunctions have been implicated [5]. BD has been reported worldwide, but has a distinct geographic distribution, with highest prevalences in countries along the ancient silk route. Although much has been learned during recent years on the pathogenesis and treatment of the disease, it is still an important cause of morbidity and mortality in areas where it is prevalent [3]. Young individuals are most commonly affected. Male to female ratio is usually 1£¿:£¿1. The gender predominance is different according to the prevalent countries. So M£¿:£¿F ratio 1£¿:£¿1 seems to be not always correct [4]. Ocular and central nervous system involvement are the basic prognostic factors in BD. Cardiovascular, pulmonary, and gastrointestinal system involvements are the major causes of mortality. In different series, high prevalence of ocular, nervous system, pulmonary system involvement, large vessel thrombosis, thrombophlebitis and patergy positivity has been found in male patients, and in view of these data a more severe course in male patients can be expected. Higher incidence of severe clinical course and systemic involvement is observed when early onset of the disease is present [2¨C4]. 2. Ulcerative Clinical Manifestations Ulcerative lesions in BD are regarded as important manifestation for diagnosis. Various kinds of ulcerative mucocutaneous and Gis lesions appear in patients with BD. 2.1. Mucocutaneous Ulcerative
%U http://www.hindawi.com/journals/ulcers/2012/146797/