%0 Journal Article
%T Drug Resistance Pattern of MTB Isolates from PTB Patients
%A Rajani Ranganath
%A Vijay G. S. Kumar
%A Ravi Ranganath
%A Gangadhar Goud
%A Veerabhadra Javali
%J Tuberculosis Research and Treatment
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/862530
%X Background. TB is a global pandemic disease. All TB control programs were not successful due to the emergence of multidrug resistance in M. tuberculosis strains. Objective of the present study was to detect the rate of MDR-MTB in this part of India. Methods. One hundred and thirty clinical MTB strains isolated from patients on treatment and confirmed as MTB by MPT64 antigen detection were tested for drug susceptibility against Streptomycin, INH, Rifampicin, and Ethambutol by MBBact automated system. Result. Thirty-two were MDRs (25.61%). 31.2%, 28%, 17.6%, and 21.6% were resistant to INH, RIF, Ethambutol, and Streptomycin, respectively. Resistance to either INH or Rifampicin was 20.8% and 13.88%, respectively. Combined INH and Rifampicin resistance was seen in 18.05% isolates. Conclusion. Drug resistance rate is high in patients treated previously and who have been irregular on treatment. 1. Introduction Tuberculosis (TB) is the second leading cause of death from an infectious disease worldwide after human immunodeficiency virus (HIV). Inspite of free supply of drugs, 1.4 million TB deaths occurred worldwide in 2011. Recently, World Health Organization has estimated that 3.7% of new TB cases are MDRs. MDR-TB global average rate is 20%. About 9% of these cases also are resistant to at least one injectable second line antitubercular drugs. These strains are called extensively drug resistant (XDR) TB cases [1]. During the middle of twentieth century, tuberculosis rate in Europe and North America decreased to an extent that it was thought as totally eradicated. Health care providers started to announce that TB is eradicated. TB sanatoriums were closed. But M. tuberculosis bounced back in 1980s with a vengeance and has spread all over the world. Unholy nexus between TB and HIV has further increased not only TB rate but also mortality. Drug resistance (DR) in MTB is a manmade problem. Defaulting by the patient, poor quality of drugs and lack of awareness have contributed to the present grim situation of TB management. In 1993, increasing reports of MDRTB were noted from USA [2] and WHO declared TB as global emergency [3]. WHO¡¯s millennium development goal to reduce TB by 2015 has failed. Drug resistance in MTB is manmade and is a consequence of suboptimal regimens and treatment interruptions [4]. MTB strains exhibiting resistance to INH and Rifampicin, the two main first line drugs, are designated as MDRTB strains. These MDR strains require prolonged treatment using second line drugs which are highly toxic and less effective [5, 6]. WHO and International
%U http://www.hindawi.com/journals/trt/2013/862530/