%0 Journal Article
%T The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women
%A Irma B. Ancheta
%A Cynthia A. Battie
%A Dan Richard
%A Christine V. Ancheta
%A Nancy Borja-Hart
%A Annabelle S. Volgman
%A Yvette Conley
%J Nursing Research and Practice
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/328954
%X The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, ) participating in health screenings in four cities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk allele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg. Genotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level ( ). Approximately 60% of participants regardless of genotype exhibited LDL-C levels 100£¿mg/dL but were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs. 1. Introduction Coronary heart disease is a multifactorial and complex disease resulting from the interaction of genes and environmental factors [1¨C5]. Genetics plays an important role in determining the inherent CHD vulnerability and in determining how a person responds to statin therapy. KIF6 is a member of the kinesin family, a class of motor proteins that are involved in the intracellular transport of membrane organelles, messenger RNA¡¯s and other protein complexes along microtubules [6¨C10]. Several studies focusing on Caucasians have reported that the Trp719Arg allele of single nucleotide polymorphism (SNP) rs20455 in the KIF6 gene is associated with CHD and that carriers who carry one or two copies of the risk allele respond better to statin therapy than noncarriers [10¨C15]. The prevalence among Caucasians is about 59% and the risk ratio has been stated to be 1.22 (95% confidence intervals 1.12¨C1.32) [15]. This association with increased risk was present in African Americans, who have very high numbers (~90%) with the risk allele [15]. Chinese and Japanese also have been reported to have a high frequency (~70%) of the risk allele [15]. Other investigators were unable to detect the association of the rs20455 allele with increased CHD risk [16] even with a large sample size [17].
%U http://www.hindawi.com/journals/nrp/2014/328954/