%0 Journal Article
%T Assessing Relapse in Multiple Sclerosis Questionnaire: Results of a Pilot Study
%A Amy Perrin Ross
%A Alona Williamson
%A Jennifer Smrtka
%A Tracy Flemming Tracy
%A Carol Saunders
%A Constance Easterling
%A John Niewoehner
%A Nicole Mutschler
%J Multiple Sclerosis International
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/470476
%X There is need for a brief but comprehensive objective assessment tool to help clinicians evaluate relapse symptoms in patients with multiple sclerosis (MS) and their impact on daily functioning, as well as response to treatment. The 2-part Assessing Relapse in Multiple Sclerosis (ARMS) questionnaire was developed to achieve these aims. Part 1 consists of 7 questions that evaluate relapse symptoms, impact on activities of daily living (ADL), overall functioning, and response to treatment for previous relapses. Part 2 consists of 7 questions that evaluate treatment response in terms of symptom relief, functioning, and tolerability. The ARMS questionnaire has been evaluated in 103 patients with MS. The most commonly reported relapse symptoms were numbness/tingling (67%), fatigue (58%), and leg/foot weakness (55%). Over half of patients reported that ADL or overall functioning were affected very much (47%) or severely (11%) by relapses. Prescribed treatments for relapses included intravenous and/or oral corticosteroids (87%) and adrenocorticotropic hormone (13%). Nearly half of patients reported that their symptoms were very much (33%) or completely resolved (16%) following treatment. The most commonly reported adverse events were sleep disturbance (45%), mood changes (33%), weight gain (29%), and increased appetite (26%). Systematic assessment of relapses and response to relapse treatment may help clinicians to optimize outcomes for MS patients. 1. Introduction Multiple sclerosis (MS), particularly relapsing remitting MS (RRMS), the most common form of the disease, is characterized by relapses [1, 2]. These events vary considerably with respect to both the type and severity of symptoms [3, 4]. Relapses are cardinal events for patients with MS. They are associated with significant disability and increased cost of care; and they may result in residual deficits after resolution of the acute event [1¨C5]. Although relapses can be expected to resolve over time without intervention [2], treatment with high-dose corticosteroids or adrenocorticotropic hormone (ACTH) (e.g., H.P. Acthar Gel, repository corticotropin injection; Questcor Pharmaceuticals, Inc., Hayward, CA, USA) can shorten the time to recovery [6]. Assessment tools, such as the Expanded Disability Status Scale (EDSS) [7] and Multiple Sclerosis Functional Composite (MSFC) [8], have been developed to evaluate the status of patients and disease progression in MS patients not experiencing relapses. There is also need for a tool to facilitate identification of relapses, determination of symptom severity,
%U http://www.hindawi.com/journals/msi/2013/470476/