%0 Journal Article
%T Self-Microemulsifying Drug Delivery System: Formulation and Study Intestinal Permeability of Ibuprofen in Rats
%A Bharat Bhushan Subudhi
%A Surjyanarayan Mandal
%J Journal of Pharmaceutics
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/328769
%X The study was aimed at developing a self-microemulsifying drug delivery system (SMEDDS) of Ibuprofen for investigating its intestinal transport behavior using the single-pass intestinal perfusion (SPIP) method in rat. Methods. Ibuprofen loaded SMEDDS (ISMEDDS) was developed and was characterized. The permeability behavior of Ibuprofen over three different concentrations (20, 30, and 40£¿¦Ìg/mL) was studied in each isolated region of rat intestine by SPIP method at a flow rate of 0.2£¿mL/min. The human intestinal permeability was predicted using the Lawrence compartment absorption and transit (CAT) model since effective permeability coefficients ( ) values for rat are highly correlated with those of human, and comparative intestinal permeability of Ibuprofen was carried out with plain drug suspension (PDS) and marketed formulation (MF). Results. The developed ISMEDDS was stable, emulsified upon mild agitation with 44.4£¿nm ¡À 2.13 and 98.86% ¡À 1.21 as globule size and drug content, respectively. Higher in colon with no significant difference in jejunum, duodenum, and ileum was observed. The estimated human absorption of Ibuprofen for the SMEDDS was higher than that for PDS and MF . Conclusion. Developed ISMEDDS would possibly be advantageous in terms of minimized side effect, increased bioavailability, and hence the patient compliance. 1. Introduction In recent years, much attention has been focused on using emulsion drug delivery system for the purpose of improving the solubility and oral absorption of poorly water-soluble drugs [1¨C3]. SMEDDSs are defined as isotropic mixtures of natural or synthetic oils, solid or liquid surfactants, or, alternatively, one or more hydrophilic solvents and cosolvents/surfactants that have a unique ability of forming fine oil-in-water (o/w) microemulsions upon mild agitation followed by dilution in aqueous media, such as GI fluids [4]. SMEDDSs spread readily in the GI tract, and the digestive motility of the stomach and the intestine provide the agitation necessary for self-emulsification. SMEDDS is optically clear and thermodynamically stable system with a droplet size less than 100£¿nm. This system has been shown to improve absorption of drugs due to small droplet size and promotes intestinal lymphatic transport due to its specific components [5]. Ibuprofen (2-(4-(2-methylpropyl)phenyl) propanoic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for relief of symptoms of arthritis and fever. Ibuprofen is a poor water-soluble drug, and absorption in rats was shown to occur mainly from the intestine and to a lesser,
%U http://www.hindawi.com/journals/jphar/2013/328769/