%0 Journal Article
%T Is Hyperopia an Important Risk Factor for PACG in the Dutch Population?¡ªA Case Control Study
%A Saskia H. M. van Romunde
%A Gijs Thepass
%A Hans G. Lemij
%J Journal of Ophthalmology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/630481
%X Objectives. To determine if hyperopia is a risk factor for primary angle-closure glaucoma (PACG) in the Dutch population and to identify other biometrical parameters as risk factors for PACG including axial length (AL), anterior chamber depth (ACD), and values. Methods. The study population consisted of PACG patients that had undergone a laser peripheral iridotomy (LPI). The control group consisted of age- and gender-matched cataract patients. The main outcome was hyperopia (spherical equivalent ¡Ý+0.5 dioptres) measured with IOL Master or autorefractor. Refractive error, ACD, AL, and values were tested with a Mann-Whitney test and by logistic regression. Results. 117 PACG patients and 234 controls were included (mean age = 80 years ¡À 3.6). The prevalence of hyperopia in patients and controls was 69.6% and 61.1%, respectively (Fisher¡¯s test ). Mann-Whitney test showed no statistically significant relation with refractive error ( ) or values ( ). In contrast, ACD and AL were statistically significant ( ). Tested with logistic regression, only ACD was a significant predictor of PACG ( ). Conclusion. There was no statistically significant correlation between refractive error and PACG. ACD was strongly correlated, though, with PACG, whereas AL turned out to be a less significant risk factor. 1. Introduction Glaucoma is the most important cause of irreversible blindness in the world [1]. Primary angle-closure glaucoma (PACG) is highly prevalent in Asian countries. However, the Egna-Neumarkt Glaucoma Study stated that the burden of PACG in Europe has been underestimated previously [2]. The prevalence in this study was 0.6%, which accounts for about a quarter of all primary glaucoma cases. The most frequent type was chronic angle closure, which is more insidious and hence more often missed. Further damage of PACG can be easily prevented by performing a laser peripheral iridotomy (LPI) [3]. It is important to know more about the pathophysiology and risk factors for PACG to improve prevention. Several risk factors have been identified for PACG, including female gender, older age, and shallow anterior chamber depth (ACD) [2, 4¨C8]. Ophthalmologists in Europe commonly have the clinical impression that hyperopia is a risk factor for PACG. The relation between hyperopia and PACG was suggested as early as in 1970 [9]. Despite several studies, however, this relation has not been convincingly proven [4, 6¨C8]. A possible explanation for the mismatch between the clinical impression of such a relationship and the lack of evidence might be that most researches have been done
%U http://www.hindawi.com/journals/joph/2013/630481/