%0 Journal Article
%T Waist Circumference as Measure of Abdominal Fat Compartments
%A Scott M. Grundy
%A Ian J. Neeland
%A Aslan T. Turer
%A Gloria Lena Vega
%J Journal of Obesity
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/454285
%X This study examines intercorrelations among waist circumference (WC), intraperitoneal fat (IPF), and subcutaneous abdominal fat (SAF) in ethnically diverse Dallas Heart Study consisting of 1538 women and 1212 men (50% Black). Correlations between fat depots and triglyceride or HOMA2-IR, biomarkers of metabolic syndrome, are also reported. Total abdominal fat (TAF), ASF, and IPF masses were measured by magnetic resonance imaging. The highest correlations with WC according to ethnicity and gender were noted for TAF with progressively lower correlations with ASF (0.65¨C0.82) and IPF (0.29¨C0.85). The percentage of IPF relative to TAF was not significantly correlated with WC. For all WC categories, higher IPF/ASF ratios were associated with higher triglyceride levels. In contrast, differences in ratios had little or no association with HOMA2-IR. However, when all data were pooled, IPF was positively correlated with both triglyceride ( (men) and 0.363 (women)) and HOMA2-IR ( (men) and 0.517 (women)); after adjustment for ASF, IPF was still correlated with triglyceride ( (men) and 0.348 (women)) and HOMA2-IR ( (men) and 0.221 (women)). WC measures TAF reliably, but its association with IPF depends on IPF/ASF ratios that vary by gender and ethnicity. 1. Introduction Abdominal obesity is one component of the metabolic syndrome [1]. Clinically, abdominal obesity is identified by an increase in waist circumference (WC). Increased WC has repeatedly been linked to metabolic risk. It is unclear, however, whether this measure is a correlate of increased risk through its correlation with total abdominal fat (TAF) or a specific, metabolically unhealthy depot of adipose tissue. Many investigators postulate that the key component of body fat underlying the metabolic syndrome is intraperitoneal fat (IPF) or visceral fat [2¨C7]. Others nonetheless contend that abdominal subcutaneous fat (ASF) is a more important pathogenic factor [8¨C14]. Since previous studies have shown that IPF and ASF are intercorrelated [15], the more important adipose-tissue compartment underlying the metabolic syndrome is difficult to identify. The primary aim of this study was to determine the strength of the correlations between WC and TAF, and ASF and IPF measured by magnetic resonance imaging (MRI). These analyses were made for gender in whites, blacks, and Hispanics of the Dallas Heart Study [16]. We additionally correlated SAF and IPF with plasma triglyceride (TG) and homeostatic model assessment of insulin resistance (HOMA2-IR) [17], both accompanying the metabolic syndrome. 2. Methods Details of
%U http://www.hindawi.com/journals/jobe/2013/454285/