%0 Journal Article
%T A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension
%A Zhao-min Liu
%A Suzanne C. Ho
%A Yu-ming Chen
%A Jean Woo
%J Journal of Obesity
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/359763
%X Objectives. This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers. Methods. 270 eligible women were randomized to either one of the three treatments: 40£¿g soy flour (whole soy group), 40£¿g low-fat milk powder + 63£¿mg daidzein (daidzein group), or 40£¿g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention. Results. 253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass. Conclusion. Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.gov NCT01270737. 1. Introduction Overweight and obesity are important clinical and public health burdens worldwide affecting more than 30% of adult population [1]. Aging- and menopause-induced estrogen deficiency results in an increase in body weight or abdominal fat and a decrease in lean mass which contribute to an elevated risk of cardiovascular diseases (CVD) and other metabolic disorders [2, 3]. Diet therapy has the lowest side effects for the prevention and management of postmenopausal obesity relative to hormone replacement therapy [4]. Soy is a traditional Asian diet and also a rich source of plant protein, unsaturated fat, dietary fiber, isoflavones (one major phytoestrogen), saponin, and so forth with a potential role on fat mass reduction and weight control. Laboratory and animal studies are generally supportive for soy and/or its components when isocaloric diets are administered to promote weight and fat loss by increasing energy utilization [5], reducing fat accumulation [6], and promoting a select loss of visceral adipose tissue [7] with more benefits than those ofcasein or other animal foods [8, 9]. Several observational studies [10¨C12], but not all [13], have reported that soy or isoflavone correlated with lower body mass
%U http://www.hindawi.com/journals/jobe/2013/359763/