%0 Journal Article
%T Increasing Possibilities of Nanosuspension
%A Kumar Bishwajit Sutradhar
%A Sabera Khatun
%A Irin Parven Luna
%J Journal of Nanotechnology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/346581
%X Nowadays, a very large proportion of new drug candidates emerging from drug discovery programmes are water insoluble and thus poorly bioavailable. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Nano refers to particles size range of 1¨C1000£¿nm. The reduction of drug particles into the submicron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Nanosuspensions are part of nanotechnology. This interacts with the body at subcellular (i.e., molecular) scales with a high degree of specificity and can be potentially translated into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic efficacy with minimal side effects. Production of drugs as nanosuspensions can be developed for drug delivery systems as an oral formulation and nonoral administration. Here, this review describes the methods of pharmaceutical nanosuspension production including advantages and disadvantages, potential benefits, characterization tests, and pharmaceutical applications in drug delivery. 1. Introduction One of the problems facing nanotechnology is the confusion and disagreement among experts about its definition. Nanotechnology is an umbrella term used to define the products, processes, and properties at the nano-microscale that have resulted from the convergence of the physical, chemical, and life sciences. The National Nanotechnology Initiative (NNI) defines, ¡°Nanotechnology as research and development at the atomic, molecular, or macromolecular levels in the sub-100-nm range (w0.1¨C100£¿nm) to create structures, devices, and systems that have novel functional properties¡± [1]. A complete list of the potential applications of nanotechnology is too vast and diverse to discuss in detail, but without doubt, one of the greatest values of nanotechnology will be in the development of new and effective medical treatments [2]. In few words, nanotechnology can be said as ¡°the technology at nanoscale¡± [3]. 2. Nanomedicine Burgeoning interest in the medical applications of nanotechnology has led to the emergence of a new field called nanomedicine, which involves the use of nanotechnology in drug development and offers ever more exciting promises of new diagnoses and cures [4]. It has been defined as ¡°the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and nanostructures.¡± Therefore, nanomedicine adopts the concepts of nanoscale manipulation and
%U http://www.hindawi.com/journals/jnt/2013/346581/