%0 Journal Article
%T Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation
%A Biswa Mohan Sahoo
%A B. V. V. Ravi Kumar
%A Jnyanaranjan Panda
%A S. C. Dinda
%J Journal of Nanoparticles
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/780786
%X A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data. 1. Introduction One-pot multicomponent organic reactions (MCORs) have emerged as an efficient tool for benign synthesis by virtue of their convergence, productivity, facile execution, and generation of highly diverse and complex products from easily available starting materials in a single operation. MCORs are now being tuned for synthesizing various heterocyclic compounds due to their diverse biological activities [1]. The environmental acceptability of the process is improved if the multicomponent strategy is applied under microwave irradiation (MWI) technology [2]. For an organic synthesis, a major adverse effect on the environment is the consumption of energy for heating. To overcome this problem, it is highly desirable to develop suitable methods of heating that use microwave irradiation. So, the synthetic methodologies nowadays should be designed in such a way to use and generate substances that possess little or no toxicity to human health and the environment. Microwave heating provides a valuable tool to perform reactions faster with enhanced product yields with high purity by reducing unwanted formation of byproducts [3]. From an environmental and economic perspective, it is becoming obvious that the traditional methods of performing chemical synthesis are unsustainable and have to be changed. Multicomponent coupling reactions provide a solution since they are more efficient, cost effective, and less wasteful than traditional methods. The achievement of making multiple bonds in a one-pot multicomponent coupling reaction promotes a sustainable synthetic approach to develop new drug molecule in a drug discovery process. Microwave (MW) irradiation facilitates better thermal management of chemical reactions. The rapid MW heat transfer allows reactions to be carried out very much faster compared to conventional heating methods often resulting
%U http://www.hindawi.com/journals/jnp/2013/780786/