%0 Journal Article
%T Epidemiology of Human Respiratory Viruses in Children with Acute Respiratory Tract Infections in Jinan, China
%A Yanqin Lu
%A Shifu Wang
%A Lehai Zhang
%A Chao Xu
%A Cuirong Bian
%A Zhaoxia Wang
%A Yanhui Ma
%A Ke Wang
%A Lixia Ma
%A Chen Meng
%A Caiyun Ni
%A Jiabei Tong
%A Gongchao Li
%A Jinxiang Han
%J Journal of Immunology Research
%D 2013
%R 10.1155/2013/210490
%X The viral etiologies of UTRIs and LTRIs in children in Jinan city were investigated between July 2009 and June 2010. Nasal and throat swabs were collected from 397 children with URTIs and bronchoalveolar lavage fluid specimens were collected from 323 children with LRTIs. RT-PCR/PCR was used to examine all samples for IFV, PIV, RSV, RV, hMPV, HBoV, CoV, ADV, RSV, and EV. Viral pathogens were detected in 47.10% of URTI samples and 66.57% samples, and the incidence of viral coinfection was 5.29% and 21.05%, respectively. IFV was the most common virus in URTIs, with a detection rate of 19.40%, followed by PIV (10.83%), RV (10.58%), and EV (6.30%). For LRTIs, PIV and RV were both detected in 27% of samples, followed by RSV (9.91%), HBoV (8.36%), IFV (5.57%), and hMPV (5.57%). RSV and HBoV were more prevalent in the youngest children of no more than six months. Meanwhile, RV, PIV, and RSV were the most frequent viruses combined with bacterial pathogens in LRTIs. In conclusion, the spectrum of respiratory virus infections in URTIs and LRTIs differed in terms of the most common pathogens, seasonal distribution, and coinfection rate. 1. Introduction Acute respiratory tract infection (ARTI) is a persistent and pervasive public health issue and a great burden to both families and the wider society. Acute low respiratory tract infection is a particular problem, being the principal cause of morbidity and mortality in young people worldwide [1¨C3]. The most common viral causes of ARTI worldwide include respiratory syncytial virus (RSV), parainfluenza viruses (PIVs), influenza viruses (IFVs), enteroviruses (EVs), adenoviruses (ADVs), human rhinoviruses (HRVs), human metapneumovirus (hMPV), and human coronaviruses (HCoVs) 229E, OC43, NL63, and HKU1. There are an increasing number of cases with severe acute respiratory syndrome caused by coronaviruses, including NL63, HKU1 [4¨C6], and human bocavirus [7], and the WU and KI polyomaviruses have been discovered to cause acute respiratory tract infections [8, 9]. The pattern of respiratory tract infections is variable and is related to factors that include region, season, and year [10, 11]. The virologic epidemiology of ARTIs in children has been investigated in various regions [12¨C14]. In this study, we aimed to characterize the viral spectrum and pattern of upper and lower ARTIs in children in Shandong province, China. 2. Materials and Methods 2.1. Ethics Statement The study followed the Declaration of Helsinki on medical protocol and ethics. The Ethics Committees of both Shandong Medicinal Biotechnology Centre and Qilu
%U http://www.hindawi.com/journals/jir/2013/210490/