%0 Journal Article
%T The Effects of Glucose Fluctuation on the Severity of Coronary Artery Disease in Type 2 Diabetes Mellitus
%A Xingguang Zhang
%A Xiuping Xu
%A Xiumin Jiao
%A Jinxiao Wu
%A Shujing Zhou
%A Xiaofeng Lv
%J Journal of Diabetes Research
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/576916
%X Objectives. To explore the difference of glucose fluctuations between the normal subjects and diabetes mellitus (DM) patients and explore their impact on the development of CAD in type 2 DM patients. Methods. The subjects were divided into 3 groups: normal control (group A, ), type 2 DM patients without cardiovascular complications (group B, ), and type 2 DM patients with cardiovascular complications (group C, ). The SYNTAX scores were collected in group C. CGMS for 72£¿h was applied on all the subjects. The indexes such as MBG and the LAGE were calculated. Glycemic excursions were compared between groups A, B, and C, respectively. Results. The tested indexes had significant differences among the three groups. SYNTAX scores are related to systolic blood pressure, CRP, MAGE, and HbA1c and are significantly correlated at 6:00¨C8:00 and 11:00¨C13:00 time points in group C. Conclusions. Compared with normal subjects, T2DM patients have greater blood glucose fluctuations; T2DM patients with CAD have larger glucose fluctuations than T2DM patients without CAD. Blood glucose fluctuations are positively correlated with carotid artery intima-media thickness in T2DM patients and have a significant influence on the development of coronary artery. 1. Introduction The incidence of type 2 diabetes mellitus (T2DM) is increasing these years with the improvement of people's living standard, the changes of life style, and the increasing aging population. Yang et al. reported that the prevalence of diabetes in adults over 20 years old was 9.7% and the prevalence of prediabetes (impaired fasting glycaemia and impaired glucose tolerance) has reached 15.5% [1]. The complications of T2DM almost involved each organ of the body; 60%¨C80% of the patients died of vascular disease [2]. Large vascular disease affects the aorta, coronary artery, cerebral artery, renal artery, and peripheral artery mainly, which is hard to ignore; many researchers have studied the effect of blood glucose fluctuation on the vascular complications of T2DM [3¨C6]. Quagliaro et al. confirmed that the blood vessel endothelium was damaged greater by blood glucose fluctuation than by chronic persistent hyperglycemia [6]; recent studies have demonstrated that acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus patients [7], which results in cell dysfunction and tissue injury [8]. Therefore, it is important to evaluate the relationship between the blood glucose fluctuation and the coronary artery disease by dynamic glucose monitoring. Su et al. [9] have
%U http://www.hindawi.com/journals/jdr/2013/576916/