%0 Journal Article
%T Trends in Breast Cancer Incidence Rates by Age and Stage at Diagnosis in Gharbiah, Egypt, over 10 Years (1999每2008)
%A Kelly A. Hirko
%A Amr S. Soliman
%A Ahmed Hablas
%A Ibrahim A. Seifeldin
%A Mohamed Ramadan
%A Mousumi Banerjee
%A Joe B. Harford
%A Robert M. Chamberlain
%A Sofia D. Merajver
%J Journal of Cancer Epidemiology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/916394
%X Background. This study was undertaken to evaluate trends in breast cancer incidence in Egypt from 1999 to 2008 and to make projections for breast cancer occurrence for the years 2009每2015. Patients and Methods. We utilized joinpoint regression and average annual percent change (AAPC) measures with 95% confidence intervals (CI) to describe the trends in breast cancer incidence rates from the Gharbiah Cancer Registry by age and stage at diagnosis and to estimate expected breast cancer caseloads for 2009每2015. Results. From 1999 to 2008, the AAPC in breast cancer incidence rates in Gharbiah significantly increased among women 50 years and older and among localized tumors (AAPC %, 95% CI, 3.1% to 8.0%). Our results predict a significant increase in breast cancer caseloads from 2009 to 2015 among women aged 30每39 (AAPC %, 95% CI, 0.9% to 1.1%) and among women aged 40每49 years (AAPC %, 95% CI, 1.0% to 2.6%). Conclusion. These results have important implications for allocating limited resources, managing treatment needs, and exploring the consequences of prior interventions and/or changing risk factors in Egypt and other developing countries at the same stages of demographic and health transitions. 1. Introduction Breast cancer rates are increasing in developing countries, including Egypt, and are largely attributed to aging of the population, delay in time of first pregnancy, decrease in number of children and in breastfeeding, and a move toward high-calorie Western diets [1每4]. Although breast cancer incidence rates in Egypt are substantially lower than the rates in the United States and other developed countries [5每7], breast cancer is the most common cancer among women in Egypt [8]. Furthermore, the current demographic trends favor the likelihood that breast cancer will become an even greater public health concern in Egypt in the future. Trends in the stage at diagnosis of breast cancer in the Gharbiah registry have not been reported, and this information is critical for evaluation of downstaging efforts. Detailed information on trends of breast cancer by stage of diagnosis may promote the reduction of disparities in the presentation of disease by focusing limited resources on the susceptible populations and can aid in our overall understanding of the etiology of breast cancer in a setting that differs in regard to its risk factor profile as compared to many developed countries. The specific aim of this study was to examine trends in breast cancer incidence by age, stage, and hormone receptor status in the Gharbiah registry from 1999 to 2008. Further, we
%U http://www.hindawi.com/journals/jce/2013/916394/