%0 Journal Article
%T A Population-Based Study of Childhood Cancer Survivors¡¯ Body Mass Index
%A Echo L. Warner
%A Mark Fluchel
%A Jennifer Wright
%A Carol Sweeney
%A Kenneth M. Boucher
%A Alison Fraser
%A Ken R. Smith
%A Antoinette M. Stroup
%A Anita Y. Kinney
%A Anne C. Kirchhoff
%J Journal of Cancer Epidemiology
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/531958
%X Background. Population-based studies are needed to estimate the prevalence of underweight or overweight/obese childhood cancer survivors. Procedure. Adult survivors (diagnosed ¡Ü20 years) were identified from the linked Utah Cancer Registry and Utah Population Database. We included survivors currently aged ¡İ20 years and ¡İ5 years from diagnosis , and a comparison cohort selected on birth year and sex . BMI was calculated from driver license data available from 2000 to 2010. Multivariable generalized linear regression models were used to calculate prevalence relative risks (RR) and 95% confidence intervals (95% CI) of BMI outcomes for survivors and the comparison cohort. Results. Average time since diagnosis was 18.5 years , and mean age at BMI for both groups was 30.5 (survivors , comparison ). Considering all diagnoses, survivors were not at higher risk for being underweight or overweight/obese than the comparison. Male central nervous system tumor survivors were overweight ( , 95% CI 1.01¨C1.23) more often than the comparison. Female survivors, who were diagnosed at age 10 and under, had a 10% higher risk of being obese than survivors diagnosed at ages 16¨C20 . Conclusion. While certain groups of childhood cancer survivors are at risk for being overweight/obese, in general they do not differ from population estimates. 1. Introduction As of 2005, there were over 328,000 childhood cancer survivors in the USA, a number that will continue to grow with emerging treatment procedures [1]. Unfortunately, survival from childhood cancer is often accompanied by an increased risk for adverse late effects from treatment [2¨C4], including cardiovascular risk [5, 6], insulin resistance [7], and neurologic, musculoskeletal, and pulmonary complications [8]. Furthermore, adult survivors of childhood cancer may be particularly prone to weight-related problems as approximately half report low levels of physical activity [9, 10]. In the general population, a high body mass index (BMI) in the overweight or obese range is associated with an increased risk for chronic health conditions including hypertension [11], diabetes [12], cancer [13], and cardiovascular disease [5, 14]. Late effects from treatment and low levels of physical activity may compound the risk of additional weight-related problems among survivors with abnormal BMIs. There is a considerable body of evidence underscoring the impact of early life exposures, such as a pediatric cancer diagnosis, on health throughout the lifespan [4]. To date, most USA studies describing childhood cancer survivors¡¯ BMI have focused
%U http://www.hindawi.com/journals/jce/2014/531958/