%0 Journal Article
%T Relationships of Cardiorespiratory Fitness with Metabolic Risk Factors, Inflammation, and Liver Transaminases in Overweight Youths
%A Dominique Bougl¨¦
%A Gautier Zunquin
%A Bruno Sesbou£¿
%A Jean-Pierre Sabatier
%J International Journal of Pediatrics
%D 2010
%I Hindawi Publishing Corporation
%R 10.1155/2010/580897
%X The aim of this study was to assess the relationships of fatness and fitness with metabolic risk factors, including liver transaminases and inflammation in obese youth, taking in account gender, age, and pubertal stage. 241 children were studied (135 girls), age years ( ), Body Mass Index z score . For girls, was significantly associated with insulin ( ), Insulin resistance (HOMA-IR) ( ), and ALT ( ); a relationship was displayed between fibrinogen and age and % fat mass (FM) ( ); for boys, relationships were found between and diastolic blood pressure and triglycerides; independent associations were also found between age and insulin, HOMA-IR and HDL cholesterol; fibrinogen and sedimentation rate were related ( ) with %FM. Their relationships are observed from young age and increase with the continuous increase of factors. This supports the need to treat overweight as soon as it is detected; improving CRF is one of the ways which could be used to prevent the complications of obesity. 1. Introduction Overweight is associated with an increased cardiovascular risk, even in youth [1, 2]. It is also associated with a decreased cardiorespiratory fitness (CRF), which is liable to contribute to obesity itself. Several large reports clearly show a relationship between decreased CRF and the occurrence of metabolic risk factors in overweight adults and youth. Whether fitness and fatness have independent influences on metabolic risk, however, is not fully explained [3, 4]. Some of the studies addressed only one individual factor [5¨C9] but most of them clustered these risks in ¡°metabolic syndrome¡± (MS) [8, 10¨C13]; MS usually associates with obesity, dyslipoproteinemia (raised triglyceride and/or reduced HDL-cholesterol levels), hypertension, and insulin resistance or diabetes, but variables included in the MS and their relative weight vary among definitions; the last of them was given by the International Diabetes Federation [14]. Nonalcoholic fatty liver disease is frequently associated with MS, so that it has been proposed as a core feature of it [15, 16]. In addition inflammation is never included in the criteria of MS, while it seems to be involved in the development of its consequences [1, 17]. The value of MS concept itself is still debated [18]. A recent WHO Expert Consultation came to the conclusions that it is not a useful diagnostic or management tool [19]. The present study assessed the respective relationships of CRF and fatness on individual components of MS, including liver transaminases as a surrogate of nonalcoholic fatty liver disease [15, 16];
%U http://www.hindawi.com/journals/ijpedi/2010/580897/