%0 Journal Article
%T Assessment of Bacterial Antibiotic Resistance Transfer in the Gut
%A Susanne Schj£¿rring
%A Karen A. Krogfelt
%J International Journal of Microbiology
%D 2011
%I Hindawi Publishing Corporation
%R 10.1155/2011/312956
%X We assessed horizontal gene transfer between bacteria in the gastrointestinal (GI) tract. During the last decades, the emergence of antibiotic resistant strains and treatment failures of bacterial infections have increased the public awareness of antibiotic usage. The use of broad spectrum antibiotics creates a selective pressure on the bacterial flora, thus increasing the emergence of multiresistant bacteria, which results in a vicious circle of treatments and emergence of new antibiotic resistant bacteria. The human gastrointestinal tract is a massive reservoir of bacteria with a potential for both receiving and transferring antibiotic resistance genes. The increased use of fermented food products and probiotics, as food supplements and health promoting products containing massive amounts of bacteria acting as either donors and/or recipients of antibiotic resistance genes in the human GI tract, also contributes to the emergence of antibiotic resistant strains. This paper deals with the assessment of antibiotic resistance gene transfer occurring in the gut. 1. Emergence of Antibiotic Resistance The introduction of antibiotics after World War I resulted in a dramatic decrease of numbers of deaths due to bacterial infections. Today, antibiotics have lost their status as the ¡°miracle drug¡± [1, 2] and ¡°treatment failure¡± is a new and often seen situation [1¨C5]. The increase of antibiotic resistance is to be blamed for this medical emergency. The sustainability of antibiotic resistance is partly due to selection of already resistant bacteria that become the new dominant population in the environment. Furthermore, antibiotic usage urges bacteria sensitive to antibiotics to become resistant in order to survive. Survival mechanisms include the acquisition of antibiotic resistance genes from other bacteria/phages (horizontal gene transfer or transduction), mutations in specific genes, and alteration of the bacterial surface. Thus continuous usage and accumulation of antibiotics in the environment has resulted in the increase of antibiotic resistant bacteria not only in Europe but also worldwide. The relationship between antibiotics used as antimicrobial growth promoters (AGPs) in production animals and the development of resistant bacteria in food products has been related to human food born infections with resistant strains. This was not easy to acknowledge. A few countries within the European Union (EU) have acted on the new research regarding the suspicious use of AGP [6]. These countries were Sweden in 1986, Norway in 1995, and Denmark in 1998-1999 [7, 8].
%U http://www.hindawi.com/journals/ijmicro/2011/312956/