%0 Journal Article
%T Syntheses and Characterization of the Coordination Compounds of N-(2-hydroxymethylphenyl)-C-(3¡ä-carboxy-2¡ä-hydroxyphenyl)thiazolidin-4-one
%A Dinesh Kumar
%A Amit Kumar
%A Durga Dass
%J International Journal of Inorganic Chemistry
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/524179
%X A dry benzene solution of the Schiff base N-(2-hydroxymethylphenyl)-3¡ä-carboxy-2¡ä-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N-(2-hydroxymethylphenyl)-C-(3¡ä-carboxy-2¡ä-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Co(II), Ni(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions and forms the monomeric coordination compounds, [M(LH)(MeOH)3] [where M = Co(II), Ni(II)], [M¡ä(LH)(MeOH)] [here M¡ä = Cd(II), UO2(VI)] and [Zr(OH)2(LH)(MeOH)]. The coordination compounds have been characterized on the bases of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, and reflectance) studies, and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are nonelectrolytes ( = 3.8¨C8.9£¿mho£¿cm2£¿mol£¿1) in DMF. A tetrahedral structure for [Cd(LH)(MeOH)] and an octahedral structure for the remaining compounds are suggested. 1. Introduction The chemistry of thiazolidin-4-ones is very well documented in the literature and has been studied extensively due to their versatile biological properties [1]. Thiazolidin-4-ones, a saturated form of thiazole with carbonyl group on fourth carbon [2], have biological activities like those that are antipsychotic [3], antitubercular [4], antibacterial [5], anticonvulsant [6], antifungal [7], amoebicidal [8], antioxidant [9], antibiotic [10], and so forth. Literature survey shows that much has been reported on the syntheses and characterization [11] of a variety of thiazolidin-4-ones, but very less is known about their coordination compounds [12¨C14]. Metal complexes play an important role in plant and animal life due to their physicochemical and biological properties. Metal ions are involved in specific interactions with antibiotics, proteins, nucleic acids, and other biomolecules [15]. Most of the drugs have improved pharmacological properties in the form of their metal complexes. Transition metal ions play a very important role in the pharmacological action of metal-based drugs and these drugs are more effective against infectious microbes than the uncomplexed drugs [16]. These facts motivate us to explore the coordination behavior of a newly synthesized thiazolidin-4-one with some transition metal ions. In this paper, we describe the syntheses and characterization of N-(2-hydroxymethylphenyl)-C-(3¡ä-carboxy-2¡ä-hydroxyphenyl)thiazolidin-4-one, LH3 (I) and its coordination compounds with Co(II), Ni(II), Cd(II), Zr(OH)2(IV), and UO2(VI) ions. The structure of Schiff base and
%U http://www.hindawi.com/journals/ijic/2013/524179/