%0 Journal Article
%T Synthesis and Studies on S-Triazine-Based Ligand and Its Metal Complexes
%A R. Shanmugakala
%A P. Tharmaraj
%A C. D. Sheela
%A C. Anitha
%J International Journal of Inorganic Chemistry
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/301086
%X Tridentate chelate complexes of ML type (where M£¿=£¿Cu(II), Ni(II), and Co(II)) have been synthesized from triazine-based ligand 4,6-bis(5-mercapto-1,3,4-thiadiazol-amine)2-phenylamino-1,3,5-triazine (BMTDT). Microanalytical data, magnetic susceptibility measurements, IR, 1H NMR, UV-vis, mass, and EPR spectral techniques were used to characterise the structure of chelates. The electronic absorption spectra and magnetic susceptibility measurements suggest that metal complexes show square pyramidal geometry. The electrochemical behavior of copper(II) complex is studied by cyclic voltammetry. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation efficiency (SHG) of the ligand and metal complexes has been found to be higher than that of urea and KDP. The antimicrobial activity of the ligand and metal(II) complexes against the species Shigella, Chromobacterium, Staphylococcus aureus, Candida albicans, and Aspergillus niger has been carried out and compared with the standard one. 1. Introduction The rapid development of pathogen resistance to most of the known antibiotics is becoming a serious health problem [1]. One possible long-term solution is the development of agents that act on unexploited bacterial targets. S-triazine derivatives have received considerable attention due to their potent biological activity such as anticancer [2], estrogen receptor modulators [3], antivirals [4], and antimalarials [5, 6]. It has been reported that triazine derivatives possess potent antimicrobial activity [7, 8]. The compounds containing thiadiazole moiety have also been found to possess antitubercular and anti-inflammatory activities [9]. Hence, our aim is to synthesis a new derivative of triazine to enhance the pharmacological activities and nonlinear properties. Here, we present the synthesis, spectral characterization, bioscreening, nonlinear optical property, and fluorescence study of ligand derived from 2-amino-5-mercapto-1,3,4-thiadiazole-2-thiol and 2-phenylamino-1,3,5-triazine and its transition metal complexes. 2. Experimental All chemicals were obtained from Aldrich Chemical & Co. and used without purification. They included carbon disulphide, hydrazine hydrate, cyanuric chloride, Cu(II)Cl2¡¤2H2O, Co(II)Cl2¡¤6H2O, and Ni(II)Cl2¡¤6H2O. The solvents ethanol, DMF, and DMSO were used after purification by the standard method described in the literature. The UV-vis spectra of the ligand and its metal complexes were recorded using a JASCO V-530
%U http://www.hindawi.com/journals/ijic/2012/301086/