%0 Journal Article
%T Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions
%A Madhu Bala
%A L. K. Mishra
%J International Journal of Inorganic Chemistry
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/902575
%X The coordination complexes of bivalent metal ions with N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide (H2bmctz, H2L-1) and N-[(1E)-1-(1H-Benzimidazol-2-yl)(phenyl)methylidene] morpholine-4-carbothiohydrazide (H2bpmctz, H2L-2) were prepared and their neutral, monoanionic, and dianionic forms of ligands of compositions [M(H2L)X2] (M= , , , , , or , X=Cl£¿ or Br£¿, and H2L=H2L-1 or H2L-2), [M(HL)2]nH2O where (M= , , , , or , H2L=H2L-1 or H2L-2, and n = 0 or 2), and [MLB]nB (M= , , , , or , B=H2O, Py, or -pic, n = 0 and n = 1 if B=H2O for Ni(II) and H2L=H2L-1 or H2L-2) have been characterised by magnetic susceptibility measurements, electrical conductance values, and spectral properties. The magnetic moment value of [M(HL2)] (M= , , or ) type complexes is consistent with high spin octahedral structure while those of [M(H2L)X2] (M= , , , , or , X=Cl£¿ or Br£¿) possess five coordinated trigonal bipyramidal geometry. The adduct complexes [MLB]¡¤nB (M= , or , B=H2O, Py, or -pic) are four coordinated planar and those of and complexes [MLB], (H2L=H2L-1 or H2L-2, B=H2O, Py or -pic) are tetrahedral. These ligands have been suggested to coordinate as tridentate (N N S) donor molecule in complexes of type [M(H2L)X2], [M(HL)2], and [MLB]. The antifungal activity of ligands and some of their metal complexes were studied and it was observed that metal complexes show higher activity than free ligand. 1. Introduction Preparation and structural aspects of various metal ions with a number of benzimidazole derivatives have been reported by one of us and a number of chemists [1¨C10]. Medicinal properties of benzimidazole derivatives have established that benzimidazoles have privileged substructures for drug design [11, 12]. The most vital benzimidazole derivatives is N-ribosyl-5,6-dimethylbenzimidazole which is axial ligand in vitamin B12 possessing selective neuropeptide YY1 receptor antagonists [13], 5-lipo xyginase inhibitor [14] and poly (ADP-ribose) polymerase inhibitors [14]. Benzimidazole derivatives are of immense interest because of their wide spectrum of biological activity such as anticancer [15], antiviral [16, 17], antihistaminic [18], antifungal [19], anti-HBV [20], antibacterial [21], antitumoral [22], antiparasitic [22], antihelminitic [23], anti-inflammatory, local analgesic, hypotensive [24], antiulcer [25], and neuro leptic cardiotonic [26]. Extensive biochemical and pharmacological studies have confirmed that various benzimidazole derivatives are effective against various strains of microorganisms [25]. The wide ranging biological and
%U http://www.hindawi.com/journals/ijic/2014/902575/