%0 Journal Article
%T Diastolic Dysfunction and Severity of Cirrhosis in Nonalcoholic Cirrhotic Patients
%A A. Salari
%A A. Shafaghi
%A M. Ofoghi
%A A. Saeidinia
%A F. Mansour-Ghanaei
%J International Journal of Hepatology
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/892876
%X Background. In this study, we evaluated the association between diastolic dysfunction severity and severity of cirrhosis in nonalcoholic cirrhotic patients. Methods. This cross-sectional study was conducted on all nonalcoholic cirrhotic patients who were admitted in Rasht Razi hospital the Cancer of Guilan Province, north of Iran, from January 2011 to March 2012. Severity of cirrhosis was evaluated by Child-Pugh score. A 12-lead surface ECG and echocardiographic studies were performed. We used a HDI 3000 (Philips ATL, Bothell, WA, USA) equipped with 2 to 4£¿MHz probes. Diastolic function was determined by an expert cardiac sonographer. Data were analyzed by SPSS for win (version16). A value less than 0.05 was considered significant. Results. Sixty-tree percent of patients were male. The mean age of patients was years. 22%, 38%, and 40% of patients were considered as child class A, B, and C, respectively. There was a significant relation between diastolic dysfunction and disease duration ( ), female gender ( ), age > 60 years ( ), and severity of cirrhosis ( ). On multivariate analysis, decreased E/A ratio ( ) and disease duration ( ) showed an independent significant relation. Conclusion. According to the relation between severity of cirrhosis and diastolic dysfunction, we recommend cardiac assessment in all child B and C cirrhotic patients. 1. Introduction Cirrhosis is a hepatic disease that presents in individuals aged 50¨C60 years, typically [1, 2]. Patients with liver cirrhosis are reported to have a hyperdynamic circulation, which is manifested as high cardiac output, decreased systemic vascular resistance, and widespread arterial vasodilatation, primarily [3, 4]. Based on many previous studies traditionally, cirrhosis is associated with cardiovascular abnormalities [5, 6]. Cirrhotic cardiomyopathy is the term used to describe a collection of characters expressive of abnormal heart structure and function in patients with cirrhosis [7, 8]. The term ¡°cirrhotic cardiomyopathy¡± is generally defined by the following clinical criteria: (1) baseline increased cardiac output but blunted ventricular response to stimuli, (2) systolic and/or diastolic dysfunction, (3) absence of overt left ventricular failure at rest, and (4) electrophysiological abnormalities including prolonged QT interval on electrocardiography and chronotropic incompetence [9¨C11]. Many patients with cirrhosis exhibit various degrees of diastolic dysfunction. Diastolic relaxation is damaged in cirrhosis. Diastolic filling consists of two parts normally: rapid, early diastolic (active)
%U http://www.hindawi.com/journals/ijh/2013/892876/