%0 Journal Article
%T Ethoxyquin: An Antioxidant Used in Animal Feed
%A Alina BŁżaszczyk
%A Aleksandra Augustyniak
%A Janusz Skolimowski
%J International Journal of Food Science
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/585931
%X Ethoxyquin (EQ, 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline) is widely used in animal feed in order to protect it against lipid peroxidation. EQ cannot be used in any food for human consumption (except spices, e.g., chili), but it can pass from feed to farmed fish, poultry, and eggs, so human beings can be exposed to this antioxidant. The manufacturer Monsanto Company (USA) performed a series of tests on ethoxyquin which showed its safety. Nevertheless, some harmful effects in animals and people occupationally exposed to it were observed in 1980ĄŻs which resulted in the new studies undertaken to reevaluate its toxicity. Here, we present the characteristics of the compound and results of the research, concerning, for example, products of its metabolism and oxidation or searching for new antioxidants on the EQ backbone. 1. Introduction During storage of animal feed many different processes may occur which alter their initial natural proprieties. First of all, lipids undergo peroxidation, the process during which they are deteriorated in a free radical autocatalytic oxidation chain reaction with atmospheric oxygen. Lipid autooxidation is a cascade phenomenon ensuring continuous delivery of free radicals, which initiate continuous peroxidation. This process results in food rancidity which manifests itself as the change of taste, scent, and color as well as decrease in shelf life of the product. Natural or synthetic antioxidants are usually used to slow down or stop lipid peroxidation and in consequence to preserve freshness of the product. Many natural antioxidants, such as tocopherols, vitamin C, flavonoids, for a short period, may be effective in food preserving, but in many cases such protection is not sufficient. Therefore synthetic antioxidants are widely used, among which BHT (butylated hydroxytoluene), BHA (butylated hydroxyanisole), and EQ (ethoxyquin) are the most frequent. However, some effects of synthetic antioxidants are not always beneficial for our health. Antioxidants such as BHA or BHT have been widely used for many years to preserve freshness, flavor, and colour of foods and animal feeds as well as to improve the stability of pharmaceuticals and cosmetics. There are many controversies about the use of these two antioxidants in foods. Some experimental studies have reported that both BHT and BHA have tumour-promoting activity [1, 2]. On the other hand, there were reports on anticarcinogenic properties of these antioxidants when they are used at low concentrations [3]. Human exposures are at least 1000-fold below those associated with any
%U http://www.hindawi.com/journals/ijfs/2013/585931/