%0 Journal Article
%T Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese
%A Jiangfang Lian
%A Jian Guo
%A Zhikui Chen
%A Qingjun Jiang
%A Huadan Ye
%A Xiaoyan Huang
%A Xi Yang
%A Yanna Ba
%A Jianqing Zhou
%A Shiwei Duan
%J Disease Markers
%D 2013
%R 10.1155/2013/215407
%X Objective. Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD). The goal of our study is to explore the association of GCKR rs780093 polymorphism with CHD in Han Chinese population. Methods and Results. A total of 568 CHD cases and 494 non-CHD controls were enrolled in the current case-control study. Genotyping was done using melting temperature shift (Tm-shift) approach. Our results also showed that GCKR rs780093 polymorphism was significantly associated with TG level ( ). Although there was no significant association between cases and controls ( ), a breakdown analysis by age yielded a significant association of GCKR rs780093 polymorphism with CHD in individuals aged 65 and older (genotype: ; df£¿=£¿2; ; allele: ; df£¿=£¿1; ). Conclusion. Our findings confirmed the contribution of GCKR rs780093 polymorphism to TG metabolism and demonstrated GCKR rs780093 as a risk factor of CHD in individuals aged 65 and older. 1. Introduction Coronary heart disease (CHD) is one of the leading causes of morbidity and death in the developed countries, and its prevalence is increasing rapidly in the developing countries [1]. CHD has become a major health burden in the world [2]. CHD is a type of complex disease caused by both environmental and genetic factors, as well as interactions among these factors [3]. CHD may lead to severe events, including sudden cardiac death (SCD) or acute myocardial infarction (AMI). CHD is heritable [4¨C6]. Although genetic factors are estimated to account for about 30¨C60% of the CHD risk [7, 8], the pathogenesis of CHD is still not fully understood. Aberrant levels of blood lipids and glucose are risk factors of CHD [9, 10]. Elevated triglyceride (TG) levels were shown to be associated with increased risk of CHD and other cardiovascular events [11]. The GCKR locus is the strongest completely novel locus implicated in TG metabolism [12]. Interestingly, GCKR is also associated with the risk of cardiovascular disease [13]. Located on chromosome 2p23, GCKR gene consists of 19 exons and encodes a protein comprising 625 amino acids [14]. GCKR is a susceptibility gene for type 2 diabetes mellitus [15]. GCKR gene product inhibits glucokinase in liver and pancreatic islet cells by binding noncovalently to form an inactive complex with glucokinase and thus plays a pivotal role in glucose homeostasis [16, 17]. Recent genome-wide association studies (GWAS) have identified that GCKR is important for modulating serum TG [18] or fasting blood glucose levels.
%U http://www.hindawi.com/journals/dm/2013/215407/