%0 Journal Article
%T Prognostic Role of MicroRNA-210 in Various Carcinomas: A Systematic Review and Meta-Analysis
%A Minmin Li
%A Xuelei Ma
%A Mei Li
%A Binglan Zhang
%A Juan Huang
%A Lei Liu
%A Yuquan Wei
%J Disease Markers
%D 2014
%R 10.1155/2014/106197
%X Objective. Many studies have shown that microRNAs (miRNAs) could play a potential role as prognostic biomarkers of tumors. The aim of this study is to summarize the global predicting role of microRNA-210 (miR-210) for survival in patients with a variety of carcinomas. Methods. Relevant literature was identified using PubMed and the information in eligible studies has been extracted. Then meta-analysis of hazard ratio (HR) was performed to evaluate the prognostic role of the miR-210 in different tumors. Results. This meta-analysis included 9 published studies dealing with various carcinomas. For recurrence free survival or disease free survival (RFS/DFS), the combined hazard ratio (HR) and 95% confidence interval (95% CI) of higher miR-210 expression were 2.47 [1.36, 4.46], which could significantly predict poor survival in general carcinomas. MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS). Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse RFS/DFS, OS, and MFS/DRFS, especially in breast cancer, which were 3.36 [2.30, 4.93], 3.29 [1.65, 6.58], and 2.85 [1.76, 4.62] separately. Conclusion. Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers. 1. Introduction The discovery of the lin-4 small noncoding RNA in C. elegans in 1993 [1] initiated research focused on the cellular function of microRNAs (miRNAs). MicroRNAs (miRNAs), which are approximately 22-nucleotide long, single stranded, regulate gene expression at posttranscriptional levels. MiRNAs exert their regulatory effect by binding the 3¡ä-UTR of their target mRNA and inhibiting target gene translation to protein [2]. Therefore, a specific miRNA may simultaneously regulate multiple targets, while a single target can be regulated by multiple miRNAs [3]. Furthermore, upstream regulation of a given miRNA can involve multiple regulators at different steps of miRNA biogenesis. Thus, miRNAs take part in crucial biological processes such as differentiation, proliferation, and apoptosis [3]. In 2002, two miRNAs, miR-15a and miR-16-1, were first revealed to be downregulated in patients with chronic lymphocytic leukemia [4]. Since then, for the past few years, numerous studies have demonstrated an involvement of miRNAs in tumor development and progression. Dysregulated miRNAs have been reported in various human cancers [5¨C9], and the expression levels of some
%U http://www.hindawi.com/journals/dm/2014/106197/