%0 Journal Article
%T Psoriatic Arthritis and Diabetes: A Population-Based Cross-Sectional Study
%A Jacob Dreiher
%A Tamar Freud
%A Arnon D. Cohen
%J Dermatology Research and Practice
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/580404
%X Background. Diabetes has been associated with psoriasis, but little is known about the association between psoriatic arthritis and diabetes. Methods. Patients diagnosed with psoriatic arthritis by a rheumatologist were compared to age- and sex-matched patients without psoriatic arthritis regarding the prevalence of diabetes in a population-based cross-sectional study using logistic multivariate models. The study was performed utilizing the medical database of Clalit, the largest healthcare provider organization in Israel. Results. The study included 549 patients with psoriatic arthritis ≡21 years and 1,098 patients without psoriatic arthritis. The prevalence of diabetes in patients with psoriatic arthritis was increased as compared to the prevalence in patients without psoriatic arthritis (15.3%ˋversus 10.7%, value = 0.008). The difference was prominent among females (18.7%ˋversus 10.3%, ) but not among males (11.2% in patients with and without psoriatic arthritis, ). In a multivariate analysis, psoriatic arthritis was associated with diabetes among females (OR = 1.60, 95% CI:ˋ1.02每2.52, ) but not among males (OR = 0.71, 95% CI:ˋ0.42每1.22, ). Conclusion. Our study suggests a possible association between psoriatic arthritis and diabetes in women. Women with psoriatic arthritis might be candidates for diabetes screening. 1. Introduction Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the combined presence of psoriasis and arthritis. It affects 5每8% of psoriasis patients and 0.05每0.24% of the general Caucasian population [1, 2]. Many patients develop progressive joint damage and disability, with a significant impact on the patient＊s functional status and quality of life, and a reduced life expectancy related to cardiovascular and respiratory causes [3, 4]. Psoriasis was reported to be associated with cardiovascular risk factors [1, 5每18]. PsA also appears to be associated with an increased cardiovascular mortality and morbidity. Several factors including smoking, dyslipidemia, hypertension, increased fibrinogen level, hypercoagulability, and decreased physical activity might explain the enhanced cardiovascular risk in patients with PsA. Under-treatment of cardiovascular morbidity also may contribute to the higher cardiovascular risk [19]. Markers of disease activity seem to be associated with increased cardiovascular mortality [4]. Nevertheless, the evidence base to support the hypothesis of increased cardiovascular risk in PsA is much less definitive than in other inflammatory joint diseases such as rheumatoid arthritis
%U http://www.hindawi.com/journals/drp/2013/580404/