%0 Journal Article
%T Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function
%A A. E. Berezin
%A A. A. Kremzer
%J Cardiology Research and Practice
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/129369
%X Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84ˋmmol/L (95% confidence interval (CI)ˋ = ˋ15.75每31.25ˋmmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio , 95% CIˋ=ˋ1.20每1.82; ), osteopontin ( , 95% CIˋ=ˋ1.12每1.25; ), osteoprotegerin ( , 95% CIˋˋ=ˋˋ1.20每1.89; ), type 2 diabetes mellitus ( , 95% CIˋˋ=ˋˋ1.20每1.72; ), and total cholesterol ( , 95% CIˋ=ˋ1.10每1.22; ) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9ˋmmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease. 1. Background Hyperuricemia is frequently present in patients with symptomatic heart failure, acute coronary syndromes, arterial hypertension, and atrial fibrillation and in patients with type 2 diabetes mellitus [1每3]. Current evidence suggests that serum uric acid could be a marker of oxidative damage [4]. Serum uric acid is also considered a useful biomarker for mortality and an indicator of a poor prognosis in high-risk patients with several cardiovascular diseases [5每7]. Recently clinical studies have shown that serum uric acid inversely correlates with left ventricular ejection fraction, serum creatinine, and blood urea nitrogen in patients with heart failure [1]. There is a significant association between serum uric acid and circulating levels of proinflammatory cytokines among subjects with chronic heart failure [8]. Serum uric acid is often discussed as a risk factor for acute kidney injury, which adversely affects renal blood flow autoregulation, glomerular filtration rate, and promotes inflammation and angiogenesis [9]. However, the principal mechanism that contributes to biological effects of serum uric acid in patients with asymptomatic coronary artery disease without reducing left ventricular pump function is still to be understood. It has been postulated that serum uric acid plays a pivotal role in the pathogenesis of cardiovascular diseases affecting xanthine oxidase pathway that contributes to the production
%U http://www.hindawi.com/journals/crp/2013/129369/