%0 Journal Article
%T Restless Legs Syndrome as a Comorbidity in Rheumatoid Arthritis
%A John A. Gjevre
%A Regina M. Taylor Gjevre
%J Autoimmune Diseases
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/352782
%X Rheumatoid arthritis (RA) is a multisystem disease with a complex immunologic pathophysiology. Likewise, sleep disorders can involve a complicated interplay between the neurologic pathways, immune system, and respiratory system. Recent studies have shown an elevated prevalence of sleep abnormalities in connective tissue disorders compared to the general population. Restless legs syndrome (RLS) may be present in up to 30% of RA patients. These findings may be related to cytokine release and other immunomodulatory responses. TNF-¦Á levels relate to sleep physiology and anti-TNF-¦Á therapy may improve sleep patterns. Most of the patients with this disorder can distinguish their RLS sensations from their arthritic symptoms. RLS is a common comorbidity seen with RA, and prompt recognition and treatment can improve patient quality of life. 1. Introduction Restless legs syndrome (RLS), also called Willis-Ekbom¡¯s disease, is a common clinical syndrome which consists of an uncomfortable sensation in one¡¯s legs and an irresistible desire to move them usually occurring in the evening. This disorder has been underrecognized and misunderstood by many health care providers as well as the general public. While the original description of RLS was first reported by Dr. Karl Ekbom in 1945, this entity was mainly ignored by clinicians and researchers until the late 1980s [1]. Due to the lack of clear criteria, the International Restless Legs Syndrome Study Group (IRLSSG) was formed and developed clinical criteria in 1995 [2]. Subsequently, the IRLSSG has released revised guidelines to help in the clinical diagnosis and epidemiologic research of RLS [3]. This has helped to both significantly raise awareness of this disorder as well as to further basic scientific and clinical research into RLS. 2. RLS Diagnosis and Background The Willis-Ekbom (RLS) Foundation describes this disease as a disruptive neurologic disorder that seriously affects 2-3% of the population and may affect up to 10% of the U.S. population [4]. Patients will describe an uncomfortable itching or ¡°creepy-crawling¡± sensation on the legs in the evenings, and this may impact negatively on sleep and quality of life. The 2003 IRLSSG criteria originally listed four essential criteria to clinically diagnose RLS with a 2011 revision adding a fifth criteria. 2011 Revised IRLSSG Diagnostic Criteria(1)An urge to move the legs usually but not always accompanied by or felt to be caused by uncomfortable or unpleasant sensations in the legs.(2)The urge to move the legs and any accompanying unpleasant sensations begin or
%U http://www.hindawi.com/journals/ad/2013/352782/