%0 Journal Article
%T The Application of Optical Coherence Tomography in Musculoskeletal Disease
%A Christopher Rashidifard
%A Christopher Vercollone
%A Scott Martin
%A Bin Liu
%A Mark E. Brezinski
%J Arthritis
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/563268
%X Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and other MDs at early stages. Optical coherence tomography (OCT) is an infrared-based imaging, currently FDA approved in cardiology and ophthalmology, which has a resolution greater than 10 microns and acquisition rate of 120 frames/second. It has shown feasibility for imaging early OA, identifying changes prior to cartilage thinning both in vitro and in vivo in patients and in OA animal models. In addition, OCT has shown an ability to identify early rheumatoid arthritis (RA) and guide tendon repair, but has the potential for an even greater impact. Clinical trials in OA are currently underway, as well as in several other MDs. 1. Introduction Musculoskeletal diseases are one of the leading causes of disability in the United States. Fifty million adults in USA have been diagnosed with arthritis, rheumatoid arthritis, gout, systemic lupus erythematosus, or fibromyalgia, and approximately 1 in 3 people between ages 18 to 64 with diagnosed arthritis have work limitations [1, 2]. Similarly, disease of the periarticular structures, such as tendons and ligaments, contributes to additional disabilities and limitations. Full- or partial-thickness tears of rotator cuff tendons (RCT) are relatively common; they occur in approximately 30% of the population and represent around 4.5 million clinic visits and 40,000 surgeries in the USA per year [3]. Arthritis also affects the pediatric population, with an estimate 294,000 children under the age of 18, or 1 in every 250, having some form of arthritic or rheumatologic condition [4]. Studies estimate that by the year 2030, 67 million Americans older than 18 years will have doctor-diagnosed arthritis [5]. This paper examines the potential of the new micron-scale imaging technology and optical coherence tomography (OCT), for the management of musculoskeletal disease. It focuses on the existing clinical need for a high-resolution micron-scale imaging system in the field of orthopedics, including osteoarthritis (OA), rheumatoid arthritis (RA), and rotator cuff repair (RCR). However, this is far from the full extent of potential applications. Early detection of disease, understanding early disease markers, and accurate assessment of tissue microstructure are necessary to increase success of treatment, reduce patient morbidity, and determine the progress of future therapeutics in hopes of improving patient
%U http://www.hindawi.com/journals/arthritis/2013/563268/