%0 Journal Article
%T Interaction of Some Commercial Teas with Some Carbohydrate Metabolizing Enzymes Linked with Type-2 Diabetes: A Dietary Intervention in the Prevention of Type-2 Diabetes
%A Ganiyu Oboh
%A Omodesola O. Ogunruku
%A Funke O. Ogidiolu
%A Adedayo O. Ademiluyi
%A Bukola C. Adedayo
%A Ayokunle O. Ademosun
%J Advances in Preventive Medicine
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/534082
%X This study is aimed at assessing the inhibitory effect of teas on key enzymes ( -amylase and -glucosidase) linked with type-2 diabetes and their antioxidant properties. Four samples of three brands were used; infusions of green tea (GT), 2 brands of black tea (BT), and a formulated herbal preparation for diabetes (ADT) (white tea, Radix Puerariae, Radix ophiopogonis, hawthorn berry, Chinese yam, and fragrant Solomon seal rhizome) were prepared and subsequently analyzed for their total phenol, ascorbic acid contents, antioxidant properties (2,2-Azizobis (3-Ethylbenzo-Thiazoline~6-sulfonate) ”°ABTS”± scavenging ability and ferric reducing antioxidant property), and inhibition of pancreatic- -amylase and intestinal- -glucosidase in vitro. The study revealed that GT had the highest total phenol content, ascorbic acid content, ABTS* scavenging ability, and ferric reducing ability. Furthermore, all the teas inhibited Fe2+ and sodium nitroprusside induced lipid peroxidation in pancreas, with GT having the highest inhibitory effect. Conversely, there was no significant difference ( ) in the inhibitory effects of the teas on -amylase and -glucosidase. The antidiabetic property of the teas could be attributed to their inhibitory effect on carbohydrate hydrolyzing enzymes implicated in diabetes and their antioxidant activities. 1. Introduction Diabetes mellitus (DM) is undoubtedly one of the most challenging health problems in the 21st century; statistics show that at 2011, 366 million people are suffering from DM, a figure expected to increase to 552 million people by 2030 [1]. DM is characterized by hyperglycemia associated with abnormal metabolism of carbohydrates, fats, and proteins resulting from endocrine defects in insulin action, secretion, or both [2]. The inhibition of alpha-amylase and alpha-glucosidase, carbohydrate hydrolyzing enzymes, can significantly reduce postprandial hyperglycemia and are thus considered an important therapeutic strategy in the management of blood glucose level in type-2 diabetes [3]. Inhibition of these enzymes delays the breakdown of polysaccharides and glucose absorption, thereby reducing the amount of glucose in the blood [4]. In recent times, there has been a growing interest in medicinal plants and functional foods and their disease modulatory effects. Tea (Camellia sinensis) is the most consumed beverage in the world next to water, its consumption far exceeding beer, wine, and soft drink [5]. Teas are differentiated based on the manufacturing (fermentation) process: green tea (GT)-unfermented and black tea (BT)-fermented
%U http://www.hindawi.com/journals/apm/2014/534082/