%0 Journal Article %T A Randomized Trial Assessing the Effectiveness of Ezetimibe in South Asian Canadians with Coronary Artery Disease or Diabetes: The INFINITY Study %A Mina Madan %A Tasnim Vira %A Emmanouil Rampakakis %A Anup Gupta %A Anil Khithani %A Lyn Balleza %A Julie Vaillancourt %A Stella Boukas %A John Sampalis %A Emidio de Carolis %J Advances in Preventive Medicine %D 2012 %I Hindawi Publishing Corporation %R 10.1155/2012/103728 %X Background. There is a paucity of data regarding the effectiveness and safety of lipid-lowering treatments among South-Asian patients. Methods. Sixty-four South-Asian Canadians with coronary artery disease or diabetes and persistent hypercholesterolemia on statin therapy, were randomized to ezetimibe 10£¿mg/day co-administered with statin therapy (EZE + Statin) or doubling their current statin dose (STAT2). Primary outcome was the proportion of patients achieving target LDL-C (<2.0£¿mmol/L) after 6 weeks. Secondary outcomes included the change in lipid profile and the incidence of treatment-emergent adverse events through 12 weeks. Exploratory markers for vascular inflammation were assessed at baseline and 12 weeks. Results. At 6 weeks, the primary outcome was significantly higher among the EZE + Statin patients (68% versus 36%; ) with an OR (95% CI) of 3.97 (1.19, 13.18) upon accounting for baseline LDL-C and adjusting for age. At 12 weeks, 76% of EZE + Statin patients achieved target LDL-C compared to 48% ( ) of the STAT2 patients (adjusted OR (95% CI) = 3.31 (1.01,10.89)). No significant between-group differences in exploratory markers were observed with the exception of CRP. Conclusions. Patients receiving ezetimibe and statin were more likely to achieve target LDL-C after 6 and 12 weeks compared to patients doubling their statin dose. Ezetimibe/statin combination therapy was well tolerated among this cohort of South-Asian Canadians, without safety concerns. 1. Introduction Despite a steady decline in coronary artery disease (CAD)-related mortality over the past 25 years, CAD remains a leading cause of death among Canadians [1]. The direct association between higher serum concentrations of low-density lipoprotein cholesterol (LDL-C) and increased risk of CAD is well known [2¨C8]. In patients with primary hypercholesterolemia, the main treatment goal is lowering LDL-C to reduce CAD risk [9]. The 2009 Canadian dyslipidemia guidelines recommend treatment of patients with CAD or CAD risk equivalent conditions with an LDL-C level ¡Ý 2.0£¿mmol/L with lipid-lowering agents [9]. With declining LDL treatment targets, multiple therapies may be required to achieve these goals. Hydroxymethylglutaryl-coenzyme-A (HMG-CoA) redu-ctase inhibitors (statins) are considered first-line therapy for hypercholesterolemia [9]. For patients not achieving their target LDL-C levels, increasing the statin dose, switching to another statin, or coadministration of complementary drugs to statins may be tried. The cholesterol absorption inhibitor, ezetimibe, reduces cholesterol %U http://www.hindawi.com/journals/apm/2012/103728/