%0 Journal Article
%T The Potential Benefits and Adverse Effects of Phytic Acid Supplement in Streptozotocin-Induced Diabetic Rats
%A F. O. Omoruyi
%A A. Budiaman
%A Y. Eng
%A F. E. Olumese
%A J. L. Hoesel
%A A. Ejilemele
%A A. O. Okorodudu
%J Advances in Pharmacological Sciences
%D 2013
%I Hindawi Publishing Corporation
%R 10.1155/2013/172494
%X In this study, the effect of phytic acid supplement on streptozotocin-induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly ( ) increased by phytic acid supplementation. Systemic IL-1¦Â level was significantly ( ) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation. 1. Introduction Phytic acid (IP6) is the primary storage form of phosphorus in seeds and in some cases; it is thought to be responsible for their remarkable longevity of up to 400 years [1, 2]. Phytic acid is also found in significant quantities in roots and tubers. However, with the exception of avocado fruit, the levels of phytic acid in fruits are generally lower than the levels in seeds. Phytic acid is generally considered as an antinutrient because of its strong ability to chelate multivalent metal ions, precipitate, and decrease the availability of these minerals as a result of the formation of very insoluble salts that are poorly absorbed from the gut [3, 4]. The involvement of phosphorylated inositol (IP1 to IP6), especially IP6 in insulin secretion, has been reported [5]. For example, an extract from the skin of sweet potato has been shown to aid in the control of type II diabetes by decreasing insulin resistance in the affected patients [6]. Of note, however, is the increase intracellular concentration of D-myoinositol 1,2,3,4,5,6-hexakisphosphate (IP6) in cells that are involved in insulin secretion and several other cell types [7¨C9]. It is believed that phosphorylated inositol, especially phytic acid have roles in the
%U http://www.hindawi.com/journals/aps/2013/172494/