%0 Journal Article
%T High Incidence of HIV-1 Infection in a General Population of Fishing Communities around Lake Victoria, Uganda
%A Noah Kiwanuka
%A Ali Ssetaala
%A Annet Nalutaaya
%A Juliet Mpendo
%A Matthias Wambuzi
%A Annet Nanvubya
%A Simon Sigirenda
%A Paul Kato Kitandwe
%A Leslie Elizabeth Nielsen
%A Apolo Balyegisawa
%A Pontiano Kaleebu
%A Josephine Nalusiba
%A Nelson Kaulukusi Sewankambo
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0094932
%X Background High HIV-1 incidence rates were reported among persons in fisherfolk communities (FFC) in Uganda who were selected for high risk behaviour. We assessed the incidence of HIV-1 and associated risk factors in a general population FFC to determine population-wide HIV rates. Methods A community-based cohort study was conducted among a random sample of 2191 participants aged 18每49 years. At baseline and 12 months post-baseline, data were collected on socio-demographic characteristics and risky behaviors (including number of partners, new partners, condom use, use of alcohol and illicit drug use). Venous blood was collected for HIV serological testing. HIV incidence was calculated per 100 person years at-risk (pyar) and adjusted incidence rate ratios (Adj.IRR) were estimated by multivariable Poisson regression. Results Overall follow up at 12 months was 76.9% (1685/2191) and was significantly higher among HIV uninfected persons and those with at least 1 year duration of stay in community. Overall HIV-1 incidence was 3.39/100 pyar (95% CI: 2.55每4.49). Among the 25每29 years who drank alcohol, HIV incidence was 7.67/100pyar (95% CI;4.62每12.7) while it was 5.67/100pyar (95% CI;3.14每10.2) for 18每24 year olds who drank alcohol. The risk of HIV infection was higher among 25每29 years (adj.IRR = 3.36; 95% CI: 1.48每7.65) and 18每24 years (adj.IRR = 2.65; 95% CI: 1.05每6.70) relative to 30+ years. Compared to non-drinkers, HIV incidence increased by frequency of alcohol drinking - occasional drinkers (adj.IRR = 3.18; 95% CI: 1.18每8.57) and regular drinkers (adj.IRR = 4.93; 95% CI: 1.91每12.8). Conclusion HIV-1 incidence in general fisherfolk population along L.Victoria, Uganda, is high and is mainly associated with young age and alcohol drinking. HIV prevention and control strategies are urgently needed in this population.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0094932