%0 Journal Article
%T Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3¡ä Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
%A Mariana Ferreira Leal
%A Priscila Daniele Ramos Cirilo
%A Tatiane Katsue Furuya Mazzotti
%A Danielle Queiroz Calcagno
%A Fernanda Wisnieski
%A Samia Demachki
%A Margarita Cortes Martinez
%A Paulo Pimentel Assump£¿£¿o
%A Roger Chammas
%A Rommel Rodr¨ªguez Burbano
%A Mar¨ªlia Cardoso Smith
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0098583
%X PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0098583