%0 Journal Article
%T Genome-Wide Association Study of Proneness to Anger
%A Eric Mick
%A James McGough
%A Curtis K. Deutsch
%A Jean A. Frazier
%A David Kennedy
%A Robert J. Goldberg
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0087257
%X Background Community samples suggest that approximately 1 in 20 children and adults exhibit clinically significant anger, hostility, and aggression. Individuals with dysregulated emotional control have a greater lifetime burden of psychiatric morbidity, severe impairment in role functioning, and premature mortality due to cardiovascular disease. Methods With publically available data secured from dbGaP, we conducted a genome-wide association study of proneness to anger using the Spielberger State-Trait Anger Scale in the Atherosclerosis Risk in Communities (ARIC) study (n = 8,747). Results Subjects were, on average, 54 (range 45¨C64) years old at baseline enrollment, 47% (n = 4,117) were male, and all were of European descent by self-report. The mean Angry Temperament and Angry Reaction scores were 5.8¡À1.8 and 7.6¡À2.2. We observed a nominally significant finding (p = 2.9E-08, ¦Ë = 1.027 - corrected pgc = 2.2E-07, ¦Ë = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn. Conclusions Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density. These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087257